Correlation between plasmas levels of apelin and myocardial hypertrophy in rats and humans:Possible target for treatment?

• Type: Summary of Presentation in a National Conference
• Date: 2010

Authors

Falcão-Pires I (Author) FMUP; Gonçalves N (Author) FMUP; Gavina C (Author) FMUP; Pinho S (Author) FMUP; Teixeira T (Author) Other; Moura C (Author) FMUP; Jorge-Amorim M (Author) FMUP; Pinho P (Author) Other; Areias JC (Author) FMUP; Leite-Moreira AF (Author) FMUP

Conference proceedings National

Title: Revista Portuguesa Cardiologia

Initial page: I-29

XXXI Congresso Português de Cardiologia

Lisboa, 09 a 12 de Abril de 2010

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences > Medical sciences > Medicine > Cardiology

Other information

Resumo (PT): Research design and methods: Pressure-overload was established in rats by supra-renal aortic-banding. Six-weeks later, diabetes was induced by streptozotocin (65mg/kg,ip), resulting in 4 groups: SHAM, banded (BA), diabetic (DM) and diabetic-banded (DM-BA). Twelve weeks later, LV function and structure were evaluated by echocardiography and biopsies and plasma samples collected. Furthermore, plasma samples and LV-endomyocardial biopsies were procured from aortic stenosis and mitral stenosis patients during surgery to evaluate myocardial expression of apelin and APJ-receptor and plasma levels of apelin. Results: Direct correlations between apelin plasma levels and LV-mass index and between apelin and APJ myocardial expression were observed both in humans and rats. Expression of apelin and APJ was not significantly altered by pressure-overload in humans, being downregulated by pressure-overload and even more by diabetes in rats. Finally, an inverse correlation between apelin rat plasma levels and its myocardial expression was observed. Conclusions: While apelin/APJ myocardial expression decreases, apelin plasma levels increase in LV-hypertrophy. Considering apelin's positive inotropic and vasodilator properties, this elevation in apelin plasma levels may represent a compensatory mechanism to maintain inotropism and cardiac output during pressure-overload or diabetic cardiomyopathy.

Language: Portuguese

Type (Professor's evaluation): Scientific

Notes: XXXI Congresso Português de Cardiologia, publicado na Rev. Port. Cardiol. 2010; Vol.29(Supl.I):I-29.