Administration of apelin increases inotropism and myocardial performance in MCT-induced pulmonary hypertension.

• Type: Summary of Presentation in an International Conference
• Date: 2006

Authors

Falcão-Pires I (Author) FMUP; Henriques-Coelho T (Author) FMUP; Gonçalves N (Author) FMUP; Gonçalves D (Author) Other; Leite-Moreira AF (Author) FMUP

Conference proceedings International

Title: European Journal of Heart Failure

Pages: 171-172

ESC Annual Congress 2006

Helsínquia, Finlândia, 17 a 20 de Junho de 2006

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences > Medical sciences > Medicine > Cardiology

Other information

Resumo (PT): Apelin is the endogenous vasoactive ligand of APJ receptor. It's widely expressed in the heart and lungs and has some cardiovascular functions such as endothelium-dependent vasodilatation and positive inotropic effect. The aim of this study was to evaluated the chronic effects of apelin administration on biventricular function in a model of pulmonary hypertension (PH) induced by monocrotaJine (MCT). Methods: Male Wistar rats were randomly injected with MCT (60mg/kg, sc) or vehicle (day 0). One week later, animals treated with MCT were randomly divided and treated with Pyr-apelin-13 (200~g/kg/day, ip) or a similar volume of vehicle. The study resulted in 3 groups: CTRL; MCT and MCT+Apelin. At day 24, animals were instrumented to evaluate right(RV) and left ventricle (LV) peak systolic (Pmax) pressures, dP/dtma.x, dP/dtmin and time constant Tau. Also, heart and lungs were weighted. Results: Results are summarized on Table 1 as mean-t-SEM, p<0,05: a vs CTRL; b vs MCT. Table 1. Effects of Apelin on hemodynamic and morphologic parameters CTRL MCT MCT+AP VD/VE+Septum ( g / g ) 0 . 2 0 5±0 . 0 5 0.59±0.04a 0.40±0.06a ,b Lungs/body weight (gAg) 3.87±0.03 8.05±0.50a 6.30±0.52a ,b PVDmax (mmHg) 22.2±1.93 45.2±3.34a 30.8±2.77a ,b dP/dtmax VD (mmHg/s) 1 0 1 4±1 0 7 1646±90.7a 1175±120b PVDtele (mmHg) 0.8±0.3 1.9±0.66 2.4±0.31 a tau VD (ms) 26.6±2.1 2 2 . 1±1 . 9 6 13.5±0.90b Conclusions: Chronic administration of apelin has beneficial effects on MCT model namely, decreasing PH, RV diastolic function and hypertrophy. These results reveal the importance of apelin-APJ system in the pathophysiology of PH, suggesting that apelin is a potential therapeutic target in this disease.

Language: English

Type (Professor's evaluation): Scientific

Notes: ESC Annual Congress 2006, published in journal, European Journal of Heart Failure. 2006; Vol.5(Suppl.1):171-172.