Hereditary gastric cancer

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Oliveira C (Author) FMUP; Seruca R (Author) FMUP; Carneiro F (Author) FMUP

Journal

Title: Best Practice and Research in Clinical Gastroenterology

Vol. 23

Pages: 147-157

ISSN: 1521-6918

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 48 Citations

Scopus - 59 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-003-KYM

DOI: 10.1016/j.bpg.2009.02.003

Abstract (EN): Gastric cancer is a heterogeneous and highly prevalent disease, being the fourth most common cancer and the second leading cause of cancer associated death worldwide. Most cases are sporadic and familial clustering is observed in about 10% of the cases. Hereditary gastric cancer accounts for a very low percentage of cases (1-3%) and a single hereditary syndrome - Hereditary Diffuse Gastric Cancer (HDGC) - has been characterised. Among families that fulfil the clinical criteria for HDGC, about 40% carry CDH1 germline mutations, the genetic cause of the others being unknown. The management options for CDH1 asymptomatic germline carriers are intensive endoscopic Surveillance and prophylactic gastrectomy. In this chapter we review the pathophysiology and clinicopathological features of HDGC and discuss issues related with genetic testing and management of family members.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11