Characterization and preliminary in vivo evaluation of a novel modified hydroxyapatite produced by extrusion and spheronization techniques

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Cortez, PP (Author) ICBAS; Atayde, LM (Author) Other; Silva, MA (Author) Other; Armada da Silva, P (Author) Other; Fernandes, MH (Author) FMDUP; Américo Afonso (Author) FMDUP; Lopes, MA (Author) FEUP; Mauricio, AC (Author) ICBAS; Santos, JD (Author) FEUP

Journal

Title: Journal of Biomedical Materials Research - Part B Applied Biomaterials

Vol. 99B

Pages: 170-179

ISSN: 1552-4973

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 13 Citations

ISI Web of Science

Scopus - 19 Citations

Pubmed / Medline

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

CORDIS: Health sciences

Other information

Authenticus ID: P-002-MAH

DOI: 10.1002/jbm.b.31884

Abstract (EN): A glass-reinforced hydroxyapatite (HA) composite, recently registered as Bonelike (R), was developed for bone grafting. This biomaterial is composed of a modified HA matrix with alpha- and beta-tricalcium phosphate secondary phases and ionic species that mimic the chemical composition of human bone. Several in vitro and in vivo studies have confirmed the benefits of these properties. However, these studies were all executed with Bonelike (R) polygonal granules obtained by crushing. In this study, Bonelike (R) pellets were produced through a patented process, which required the use of techniques such as extrusion and spheronization. The final product presented a homogeneous size, a 55.1% global porosity and a spherical shape. This spherical shape permitted a better adaptation to the implantation site and improved injectability. Additionally, it also may contribute to formation of macropores as pellets packaging leaves open spaces. After implantation of Bonelike (R) polygonal granules and Bonelike (R) pellets in monocortical defects in sheep for 8 and 12 weeks, light microscopy and scanning electron microscopy showed extensive osteointegration simultaneously with bone regeneration for both presentations. Histomorphometric analysis did not reveal statistically significant differences between defects treated with Bonelike (R) polygonal granules and Bonelike (R) pellets, which suggests similar in vivo performances. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 99B: 170-179, 2011.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10