An in vitro and in vivo investigation of the biological behavior of a ferrimagnetic cement for highly focalized thermotherapy

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Ana Portela (Author) FMDUP; Vasconcelos M (Author) FMDUP; Rogério Branco (Author) FMDUP; Fátima Gartner (Author) Other; Miguel Faria (Author) Other; José Cavalheiro (Author) Other

Journal

Title: Journal of Materials Science: Materials in Medicine

Vol. 21 No. 8

Pages: 2413-2423

ISSN: 0957-4530

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 6 Citations

ISI Web of Science

Scopus - 6 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-003-4FB

Abstract (EN): The cancer treatment by local hyperthermia, using a high frequency electromagnetic field is an extensively studied subject. For this propose it was developed a ferrimagnetic cement (FC) to be injected directly into the tumor. In this study it was determined the FC injectability, its capability to generate heat when placed within a magnetic field and its interaction with a modified simulated body fluid using SEM/EDS and XRD. The FC biological response was assessed by the intramuscular implantation in rats and histological analysis of the surrounding tissues. The results suggest that FC can be injected directly into the tumor, its temperature can be increased when exposed to a magnetic field and the surface of the immersed samples quickly becomes coated with precipitate denoting its ionic change with the surrounding medium. The histological analysis revealed a transient local inflammatory reaction, similar to the control material, only slightly more abundant during the first weeks, with a gradual decrease over the implantation time. Based on these results, we concluded that FC might be useful for highly focalized thermotherapy, with a good potential for clinical use.

Language: English

Type (Professor's evaluation): Scientific