Daily digital biomarkers in the follow-up and clustering of patients with asthma

• Type: Article in International Scientific Journal
• Date: 2025

Authors

Sousa-Pinto, B (Author) FMUP; Schleich, F (Author) Other; Louis, G (Author) Other; Gemicioglu, B (Author) Other; Kvedariene, V (Author) Other; Regateiro, FS (Author) Other; Loureiro, CC (Author) Other; Taborda-Barata, L (Author) Other; Amaral, R (Author) Other; Antó, JM (Author) Other; Bedbrook, A (Author) Other; Czarlewski, W (Author) Other; Ansotegui, IJ (Author) Other; Bergmann, KC (Author) Other; Bonini, M (Author) Other; Bossios, A (Author) Other; Boulet, LP (Author) Other; Braido, F (Author) Other; Brightling, C (Author) Other; Brusselle, G (Author) Other; Brussino, L (Author) Other; Canonica, GW (Author) Other; Cruz, AA (Author) Other; Haahtela, T (Author) Other; Heaney, LG (Author) Other; Hyland, M (Author) Other; Ivancevich, JC (Author) Other; Klimek, L (Author) Other; Kulus, M (Author) Other; Kuna, P (Author) Other; Kupczyk, M (Author) Other; Larenas-Linnemann, DE (Author) Other; Makris, M (Author) Other; Marques-Cruz, M (Author) Other; Gil-Mata, S (Author) Other; Morais-Almeida, M (Author) Other; Niedoszytko, M (Author) Other; Ollert, M (Author) Other; Papadopoulos, NG (Author) Other; Patella, V (Author) Other; Pfaar, O (Author) Other; Porsbjerg, C (Author) Other; Puggioni, F (Author) Other; Quirce, S (Author) Other; Cordeiro, CR (Author) Other; Roche, N (Author) Other; Samolinski, B (Author) Other; Sastre, J (Author) Other; Scichilone, N (Author) Other; Skrgat, S (Author) Other; Toppila-Salmi, S (Author) Other; Usmani, OS (Author) Other; Valiulis, A (Author) Other; Gradauskiene, B (Author) Other; Koyuncu, IV (Author) Other; Ventura, MT (Author) Other; Vieira, RJ (Author) Other; Yorgancioglu, A (Author) Other; Fonseca, JA (Author) Other; Zuberbier, T (Author) Other; Petre, B (Author) Other; Louis, R (Author) Other; Bousquet, J (Author) Other

Journal

Title: Pulmonology

Vol. 31

ISSN: 2531-0429

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-019-STA

DOI: 10.1080/25310429.2025.2532980

Abstract (EN): Background and Research questionWe aimed to assess whether levels of digital biomarkers can reflect monthly patterns of asthma controlStudy design and methodsWe performed a longitudinal study on patients with asthma and comorbid rhinitis who filled >= 26 days of data in a month in the MASK-air (R) app and who reported at least 1 day of treatment with an inhaled corticosteroid with or without a long-acting beta 2-agonist (ICS +/- LABA). We applied k-means cluster analysis to define clusters of months according to daily asthma control and medication use. Clusters were compared using digital biomarkers (visual analogue scale [VAS] on asthma symptoms and electronic daily asthma control score [e-DASTHMA]). We compared patients who did not switch with patients who switched their ICS +/- LABA.ResultsWe assessed 243 patients and 1358 months. We identified three clusters of poor asthma control despite high ICS +/- LABA adherence, one cluster of poor asthma control and poor ICS +/- LABA adherence, one cluster of good asthma control and high ICS +/- LABA adherence and one cluster of good asthma control despite poor ICS +/- LABA adherence. These clusters displayed relevant differences in VAS asthma and e-DASTHMA levels. Similar clusters were found in 'non-switchers' versus 'switchers'.ConclusionLevels of digital biomarkers reflect asthma control patterns and might be used to monitor patients with asthma.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14