Promising Nanotechnology-Based Strategies for Melanoma Treatment

• Type: Another Publication in an International Scientific Journal
• Date: 2025

Authors

Sias-Fonseca, L (Author) Other; Costa, PC (Author) Other; Saraiva, L (Author) Other; Alves, A (Author) Other; Maria Helena Amaral (Author) FFUP

Journal

Title: Colloids and Surfaces B: Biointerfaces

Vol. 9

Final page: 53

ISSN: 0927-7765

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-019-YHX

DOI: 10.3390/colloids9040053

Abstract (EN): Melanoma is a type of skin cancer with high lethality and increasing incidence. Current treatments typically involve surgery as the first step, followed by adjuvant treatments, which are necessary in most cases. These adjuvant treatments may include radiotherapy, phototherapy, chemotherapy, immunotherapy, and combined therapies. However, patients with melanoma still face great difficulties, such as the inefficiency of therapies and serious side effects, in addition to uncomfortable scars. Most of these problems are related to limitations of antitumor therapies, such as the low bioavailability of drugs, degradation in biological fluids, rapid clearance, difficulty in reaching the tumors, the low capacity for accumulation and infiltration in tumor cells, toxicity to healthy cells, and systemic action. Thus, antitumor therapy for melanoma remains a challenge. In this line, nanotechnology has brought new perspectives and has been the subject of intensive research on the use of nanoparticles (liposomes, lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles, carbon nanotubes, dendrimers, nanogels, and biomimetic nanoparticles, among others) as carriers for the controlled release of drugs and tumor diagnosis. This work outlines the main limitations of current melanoma therapies and explores how nanoparticle-based drug delivery systems can overcome these challenges, highlighting recent research and clinical developments.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 27