The role of the proteosurfaceome and exoproteome in bacterial coaggregation

• Type: Another Publication in an International Scientific Journal
• Date: 2025

Authors

Afonso, AC (Author) FEUP; Saavedra, MJ (Author) Other; Simoes, M (Author) Other; Simoes, LC (Author) Other

Journal

Title: Biotechnology Advances

Vol. 79

ISSN: 0734-9750

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-017-QK9

DOI: 10.1016/j.biotechadv.2024.108505

Abstract (EN): Bacterial coaggregation is a critical process in multispecies biofilm formation, driven by specific molecular interactions that facilitate the adhesion and aggregation of bacterial cells. These interactions are essential for the development and persistence of complex microbial communities. This review provides a comprehensive analysis of the roles of the proteosurfaceome and exoproteome in bacterial coaggregation. The proteosurfaceome, comprising surface-bound molecules such as adhesins, drives species-specific interactions crucial for partner recognition and adhesion. In parallel, the exoproteome, particularly extracellular polymeric substances (EPS), enhances aggregate stability by reinforcing structural integrity and facilitating intercellular communication, although its direct role in coaggregation remains to be fully clarified. By integrating these perspectives, this review aims to elucidate how the proteosurfaceome and exoproteome influence bacterial coaggregation, offering insights into their combined impact on microbial community structure and function. Furthermore, we highlight existing knowledge gaps and propose directions for future research.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11