From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Santo, VE (Author) Other; Gomes, ME (Author) Other; Mano, JF (Author) Other; Rui Reis (Author) Other

Journal

Title: Nanomedicine

Vol. 7

Pages: 1045-1066

ISSN: 1743-5889

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 40 Citations

Scopus - 50 Citations

Other information

Authenticus ID: P-002-8BW

DOI: 10.2217/nnm.12.78

Abstract (EN): The field of biomaterials has advanced towards the molecular and nanoscale design of bioactive systems for tissue engineering, regenerative medicine and drug delivery. Spatial cues are displayed in the 3D extracellular matrix and can include signaling gradients, such as those observed during chemotaxis. Architectures range from the nanometer to the centimeter length scales as exemplified by extracellular matrix fibers, cells and macroscopic shapes. The main focus of this review is the application of a biomimetic approach by the combination of architectural cues, obtained through the application of micro- and nanofabrication techniques, with the ability to sequester and release growth factors and other bioactive agents in a spatiotemporal controlled manner for bone and cartilage engineering.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 22