Studies of P(L/D)LA 96/4 non-woven scaffolds and fibres; properties, wettability and cell spreading before and after intrusive treatment methods

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ella, V (Author) Other; Gomes, ME (Author) Other; Rui Reis (Author) Other; Tormala, P (Author) Other; Kellomaki, M (Author) Other

Journal

Title: Journal of Materials Science: Materials in Medicine

Vol. 18 No. 12

Pages: 1253-1261

ISSN: 0957-4530

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-004-9TR

DOI: 10.1007/s10856-007-0144-z

Abstract (EN): Poly(L/D)lactide 96/4 fibres with diameters of 50 and 80 mu m were produced. The smaller diameter fibres were carded and needle punched to form a non-woven mat. Fibres and non-woven mats were hydrolysed for a period of 20 weeks. Fibres and pressed non-woven discs were treated with low-temperature oxygen plasma and alkaline KOH hydrolysis and ethanol washing was used as a reference treatment. The non-wovens lost 50% of their tear strength after 8 weeks in vitro while the fibres still retained 65% tensile strength after 20 weeks. Hydrolysation time in KOH, treatment time and power settings of the oxygen plasma were all directly proportional to the mechanical properties of the fibres. Increasing time (and power) resulted in lower tensile properties. Rapid wetting of the scaffolds was achieved by oxygen plasma, KOH hydrolysation and ethanol washing. Cell culturing using fibroblast cell line was carried out for the treated and non-treated non-woven scaffolds. In terms of adhesion and the spreading of the cells into the scaffold, best results after 3-day culturing were obtained for the oxygen plasma treated scaffolds.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9