Plasma surface modification of chitosan membranes: Characterization and preliminary cell response studies

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Silva, SS (Author) Other; Luna, SM (Author) Other; Gomes, ME (Author) Other; Benesch, J (Author) Other; Pashkuleva, I (Author) Other; Mano, JF (Author) Other; Rui Reis (Author) Other

Journal

Title: Macromolecular Bioscience

Vol. 8

Pages: 568-576

ISSN: 1616-5187

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 119 Citations

Scopus - 125 Citations

Other information

Authenticus ID: P-003-YJ3

DOI: 10.1002/mabi.200700264

Abstract (EN): Surface modification of biomaterials is a way to tailor cell responses whilst retaining the bulk properties. In this work, chitosan membranes were prepared by solvent casting and treated with nitrogen or argon plasma at 20 W for 10-40 min. AFM indicated an increase in the surface roughness as a result of the ongoing etching process. XPS and contact angle measurements showed different surface elemental compositions and higher surface free energy. The MTS test and direct contact assays with an L929 fibroblast cell line indicated that the plasma treatment improved the cell adhesion and proliferation. Overall, the results demonstrated that such plasma treatments could significantly improve the biocompatibility of chitosan membranes and thus improve their potential in wound dressings and tissue engineering applications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9