Development of a Novel Cell Encapsulation System Based on Natural Origin Polymers for Tissue Engineering Applications

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Luna, SM (Author) Other; Gomes, ME (Author) Other; Mano, JF (Author) Other; Rui Reis (Author) Other

Journal

Title: Journal of Bioactive and Compatible Polymers

Vol. 25 No. 2

Pages: 341-359

ISSN: 0883-9115

Publisher: SAGE

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 17 Citations

Other information

Authenticus ID: P-003-5AA

DOI: 10.1177/0883911510372173

Abstract (EN): Cells microencapsulated in biocompatible semi-permeable polymeric membranes are effective as cell delivery systems while protecting the host against immune responses. In this study, cell encapsulation membranes were prepared based on carrageenan and alginate, two natural cationic polymers. Different formulations/conditions were explored to optimize the microcapsules which were characterized with respect to their morphology, mechanical stability, and cytotoxicity. Spherical-shaped microcapsules were obtained from all the polymeric systems. The iota-carrageenan/sodium alginate microcapsules exhibited the best stability and permeability, and therefore, these were selected for the cell encapsulation. These capsules provided an environment that supported cell proliferation and have the potential for tissue engineering as well as other cell-based therapy applications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19