Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Michel, MC (Author) Other; Cardozo, L (Author) Other; Chermansky, CJ (Author) Other; Francisco Cruz (Author) FMUP; Igawa, Y (Author) Other; Lee, KS (Author) Other; Sahai, A (Author) Other; Wein, AJ (Author) Other; Andersson, KE (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: PHARMACOLOGICAL REVIEWS

Vol. 75

Pages: 554-674

ISSN: 0031-6997

Publisher: AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Y-P5K

DOI: 10.1124/pharmrev.121.000523

Abstract (EN): Overactive bladder syndrome with and without urinary incontinence and related conditions, signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract dysfunction, underactive bladder, stress urinary incontinence, and nocturia are common in the general population and have a major impact on the quality of life of the affected patients and their partners. Based on the deliberations of the sub-committee on pharmacological treatments of the 7th International Consultation on Incontinence, we present a comprehensive review of established drug targets in the treatment of overactive bladder syndrome and the aforementioned related conditions and the approved drugs used in its treatment. Investigational drug targets and compounds are also reviewed. We conclude that, de-spite a range of available medical treatment options, a considerable medical need continues to exist. This is largely because the existing treatments are symptom-atic and have limited efficacy and/or tolerability, which leads to poor long-term adherence.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 121