Simulation of Cellular Changes on Optical Coherence Tomography of Human Retina

• Type: Article in International Conference Proceedings Book
• Date: 2015

Authors

Santos, M (Author) Other; Araujo, A (Author) Other; Barbeiro, S (Author) Other; Caramelo, F (Author) Other; Correia, A (Author) Other; Marques, MI (Author) Other; Pinto, L (Author) Other; Serranho, P (Author) Other; Bernardes, R (Author) Other; Morgado, M (Author) Other

Conference proceedings International

Title: 2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

Pages: 8147-8150

37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Milan, ITALY, AUG 25-29, 2015

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00K-2M9

DOI: 10.1109/embc.2015.7320285

Abstract (EN): We present a methodology to assess cell level alterations on the human retina responsible for functional changes observable in the Optical Coherence Tomography data in healthy ageing and in disease conditions, in the absence of structural alterations. The methodology is based in a 3D multilayer Monte Carlo computational model of the human retina. The optical properties of each layer are obtained by solving the Maxwell's equations for 3D domains representative of small regions of those layers, using a Discontinuous Galerkin Finite Element Method (DG-FEM). Here we present the DG-FEM Maxwell 3D model and its validation against Mie's theory for spherical scatterers. We also present an application of our methodology to the assessment of cell level alterations responsible for the OCT data in Diabetic Macular Edema. It was possible to identify which alterations are responsible for the changes observed in the OCT scans of the diseased groups.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4