Evolution of chromone-like compounds as potential antileishmanial agents, through the 21(st)century

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Silva, CFM (Author) Other; Pinto, DCGA (Author) Other; Pedro A Fernandes (Author) FCUP; Silva, AMS (Author) Other

Journal

Title: Expert Opinion on Drug Discovery

Vol. 15

Pages: 1425-1439

ISSN: 1746-0441

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00S-KYB

DOI: 10.1080/17460441.2020.1801630

Abstract (EN): Introduction Leishmaniasis is one of the most neglected diseases of modern times that mainly affects people from developing countries, with approximately 350 million people considered at risk of developing leishmaniasis. Therefore, the development of novel antileishmanial treatments is becoming the focus of numerous research groups, with the support of the World Health Organization, which hopes to eradicate this disease in the near future. Areas covered This review focuses on the interest of chromones for the development of future treatments against leishmaniasis. In addition to plant-based chromone derivatives, structure-activity relationship studies that aim to identify the optimal structural features of the chromones' antileishmanial activity are also described and discussed. Expert opinion The numerous examples of chromones depicted in this paper, allied with the SAR studies presented herein, suggest that the chromone scaffold is a privileged core for the design and development of novel antileishmanial agents. However, some concerns have been raised concerning the considerable variability observed in the results throughout the scientific bibliography. These inconsistencies may explain the absence of pharmacodynamic and pharmacokinetic studies as well as clinical trials.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15