Putting gluten back on menu - Safety assessment of polyphenol-rich wheat varieties in Celiac Disease

• Type: Article in International Scientific Journal
• Date: 2024

Authors

Dias, R (Author) Other; Mottola, I (Author) Other; Bellomo, C (Author) Other; da Silva, S (Author) Other; Milheiro, D (Author) Other; Barone, MV (Author) Other; Martinek, P (Author) Other; Victor de Freitas (Author) FCUP; Gianfrani, C (Author) Other

Journal

Title: EFSA Journal

Vol. 22

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-017-QCX

DOI: 10.2903/j.efsa.2024.e221115

Abstract (EN): This study provides a comprehensive proteomic and metabolomic analysis of novel anthocyanin- and carotenoid-rich wheat varieties to assess their immunogenicity in the context of Celiac Disease. Using (semi)-quantitative mass spectrometry, the research found that gliadin expression and peptide release, particularly those containing immunostimulatory gamma-gliadin epitopes, vary significantly across different wheat varieties. While non-targeted mass spectrometry provided valuable insights, the study acknowledged potential methodological biases, such limitations of ion current intensity as a measure of peptide abundance. Despite promising results, further research is required to determine the safety and efficacy of coloured wheat varieties for Celiac Disease patients, considering the complex interplay of gluten proteins, food processing, digestion and matrix effects. The ongoing studies hold potential for developing nutritionally beneficial wheat alternatives for Celiac Disease management.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9