Risk Factors for Infection, Predictors of Severe Disease, and Antibody Response to COVID-19 in Patients With Inflammatory Rheumatic Diseases in Portugal-A Multicenter, Nationwide Study

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Cruz Machado, AR (Author) Other; Barreira, SC (Author) Other; Bandeira, M (Author) Other; Veldhoen, M (Author) Other; Gomes, A (Author) Other; Serrano, M (Author) Other; Duarte, C (Author) Other; Rato, M (Author) Other; Fernandes, BM (Author) Other; Garcia, S (Author) Other; Pinheiro, F (Author) Other; José Bernardes (Author) FMUP; Madeira, N (Author) Other; Miguel, C (Author) Other; Torres, R (Author) Other; Silva, AB (Author) Other; Pestana, J (Author) Other; Almeida, D (Author) Other; Mazeda, C (Author) Other; Santos, FC (Author) Other; Pinto, P (Author) Other; Sousa, M (Author) Other; Parente, H (Author) Other; Sequeira, G (Author) Other; Santos, MJ (Author) Other; Fonseca, JE (Author) Other; Romao, VC (Author) Other

Journal

Title: Frontiers in Medicine

Vol. 1

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00W-VDV

DOI: 10.3389/fmed.2022.901817

Abstract (EN): ObjectiveTo identify risk factors for SARS-CoV-2 infection and for severe/critical COVID-19, and to assess the humoral response after COVID-19 in these patients. MethodsNationwide study of adult patients with inflammatory RMDs prospectively followed in the Rheumatic Diseases Portuguese Register-Reuma.pt-during the first 6 months of the pandemic. We compared patients with COVID-19 with those who did not develop the disease and patients with mild/moderate disease with those exhibiting severe/critical COVID-19. IgG antibodies against SARS-CoV-2 were measured >= 3 months after infection and results were compared with matched controls. Results162 cases of COVID-19 were registered in a total of 6,363 appointments. Patients treated with TNF inhibitors (TNFi; OR = 0.160, 95% CI 0.099-0.260, P < 0.001) and tocilizumab (OR 0.147, 95% CI 0.053-0.408, P < 0.001) had reduced odds of infection. Further, TNFi tended to be protective of severe and critical disease. Older age, major comorbidities, and rituximab were associated with an increased risk of infection and worse prognosis. Most patients with inflammatory RMDs (86.2%) developed a robust antibody response. Seroconversion was associated with symptomatic disease (OR 13.46, 95% CI 2.21-81.85, P = 0.005) and tended to be blunted by TNFi (OR 0.17, 95% CI 0.03-1.05; P = 0.057). ConclusionsTNFi and tocilizumab reduced the risk of infection by SARS-CoV-2. Treatment with TNFi also tended to reduce rates of severe disease and seroconversion. Older age, general comorbidities and rituximab were associated with increased risk for infection and worse prognosis, in line with previous reports. Most patients with RMDs developed a proper antibody response after COVID-19, particularly if they had symptomatic disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12