Effects of nintedanib in patients with limited cutaneous systemic sclerosis and interstitial lung disease

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Allanore, Y (Author) Other; Khanna, D (Author) Other; Smith, V (Author) Other; Aringer, M (Author) Other; Hoffmann-Vold, A (Author) Other; Kuwana, M (Author) Other; Merkel, PA (Author) Other; Stock, C (Author) Other; Sambevski, S (Author) Other; Denton, CP (Author) Other; Bergna, M (Author) Other; Casado, G (Author) Other; Mannucci Walter, P (Author) Other; Proudman, S (Author) Other; Stevens, W (Author) Other; Thakkar, V (Author) Other; Troy, L (Author) Other; Loeffler-Ragg, J (Author) Other; Olschewski, H (Author) Other; André, B (Author) Other; Bondue, B (Author) Other; Houssiau, F (Author) Other; Smith, V (Author) Other; Wuyts, W (Author) Other; Azevedo, V (Author) Other; Johnson, S (Author) Other; Keystone, E (Author) Other; Khalidi, N (Author) Other; Levesque, M (Author) Other; Rozas, RM (Author) Other; Silva Orellana, A (Author) Other; Huang, C (Author) Other; Li, J (Author) Other; Jiang, Z (Author) Other; Liu, Y (Author) Other; Xiao, W (Author) Other; Xu, J (Author) Other; Zeng, X (Author) Other; Zheng, Y (Author) Other; Zou, H (Author) Other; Becvar, R (Author) Other; Madsen, H (Author) Other; Søndergaard, K (Author) Other; Kilpeläinen, M (Author) Other; Myllärniemi, M (Author) Other; Agard, C (Author) Other; Allanore, Y (Author) Other; Bourdin, A (Author) Other; Cottin, V (Author) Other; Crestani, B (Author) Other; Diot, E (Author) Other; Dominique, S (Author) Other; Hachulla, E (Author) Other; Jouneau, S (Author) Other; Leroy, S (Author) Other; Nunes, H (Author) Other; Prevot, G (Author) Other; Wallaert, B (Author) Other; Wemeau, L (Author) Other; Aringer, M (Author) Other; Bewig, B (Author) Other; Blaas, S (Author) Other; Distler, J (Author) Other; Ehrchen, J (Author) Other; Ewert, R (Author) Other; Gläser, S (Author) Other; Henes, J (Author) Other; Hunzelmann, N (Author) Other; König, R (Author) Other; Kötter, I (Author) Other; Kreuter, M (Author) Other; Prasse, A (Author) Other; Schulze-Koops, H (Author) Other; Sfikakis, P (Author) Other; Vlachoyiannopoulos, P (Author) Other; Losonczy, G (Author) Other; Behera, D (Author) Other; Gayathri Devi, HJ (Author) Other; Kadel, J (Author) Other; Kawedia, M (Author) Other; Kumar, D (Author) Other; Kumar, U (Author) Other; Lokhande, R (Author) Other; Malpani, A (Author) Other; Mohan, M (Author) Other; Nalawade, A (Author) Other; Parakh, U (Author) Other; Swarnakar, R (Author) Other; Shobha, V (Author) Other; Thangakunam, B (Author) Other; Udwadia, Z (Author) Other; Henry, M (Author) Other; O'Reilly, K (Author) Other; Balbir-Gurman, A (Author) Other; Kramer, M (Author) Other; Litinsky, I (Author) Other; Rosner, I (Author) Other; Cutolo, M (Author) Other; Gabrielli, A (Author) Other; Iaccarino, L (Author) Other; Pesci, A (Author) Other; Riccieri, V (Author) Other; Vettori, S (Author) Other; Funakubo, Y (Author) Other; Inoue, Y (Author) Other; Kawakami, A (Author) Other; Kawaguchi, Y (Author) Other; Kawamura, T (Author) Other; Kondoh, Y (Author) Other; Kuwana, M (Author) Other; Nanki, T (Author) Other; Nishioka, Y (Author) Other; Nozawa, K (Author) Other; Ogura, T (Author) Other; Okamoto, M (Author) Other; Sano, H (Author) Other; Sasai, R (Author) Other; Sasaki, N (Author) Other; Suda, T (Author) Other; Takahashi, H (Author) Other; Takeuchi, T (Author) Other; Makino, S (Author) Other; Tanaka, S (Author) Other; Yamasaki, Y (Author) Other; Ch'ng, SS (Author) Other; Cheah, C (Author) Other; Kan, S (Author) Other; Raja Mohamed, RB (Author) Other; Selman, M (Author) Other; de Vries-Bouwstra, JK (Author) Other; van den Toorn, L (Author) Other; Vonk, M (Author) Other; Voskuyl, AE (Author) Other; Hoffmann-Vold, AM (Author) Other; Seip, M (Author) Other; Dankiewicz-Fares, I (Author) Other; Olesiejuk, R (Author) Other; Pulka, G (Author) Other; Szepietowski, J (Author) Other; Alves, J (Author) Other; José Bernardes (Author) FMUP; Cordeiro, A (Author) Other; Costa, J (Author) Other; Neves, S (Author) Other; Salvador, MJ (Author) Other; Alegre Sancho, J (Author) Other; Carreira Delgado, P (Author) Other; Castellví Barranco, I (Author) Other; Cifrián Martínez, J (Author) Other; Guillén del Castillo, A (Author) Other; Ovalles, JG (Author) Other; López-Longo, FJ (Author) Other; Rivera Gallego, A (Author) Other; Freire Dapena, MC (Author) Other; Román Ivorra, JA (Author) Other; Ekwall, AH (Author) Other; Maurer, B (Author) Other; Mihai, CM (Author) Other; Müller, R (Author) Other; Mahakkanukrauh, A (Author) Other; Nantiruj, K (Author) Other; Siripaitoon, B (Author) Other; Denton, CP (Author) Other; Herrick, A (Author) Other; Madhok, R (Author) Other; Maher, TM (Author) Other; West, A (Author) Other; Antin-Ozerkis, D (Author) Other; Bascom, R (Author) Other; Criner, G (Author) Other; Csuka, ME (Author) Other; Dematte D'Amico, J (Author) Other; Ettinger, N (Author) Other; Fischer, A (Author) Other; Gerbino, A (Author) Other; Gerke, A (Author) Other; Glassberg, M (Author) Other; Glazer, C (Author) Other; Golden, J (Author) Other; Gripaldo, R (Author) Other; Gupta, N (Author) Other; Hamblin, M (Author) Other; Highland, K (Author) Other; Ho, L (Author) Other; Huggins, JT (Author) Other; Hummers, L (Author) Other; Jones, L (Author) Other; Kahaleh, M (Author) Other; Khanna, D (Author) Other; Kim, H (Author) Other; Lancaster, LH (Author) Other; Luckhardt, T (Author) Other; Mayes, M (Author) Other; Mendoza Ballesteros, F (Author) Other; Mooney, J (Author) Other; Mohabir, P (Author) Other; Morrissey, B (Author) Other; Moua, T (Author) Other; Padilla, M (Author) Other; Patel, N (Author) Other; Perez, R (Author) Other; Roman, J (Author) Other; Rossman, M (Author) Other; Russell, T (Author) Other; Saketkoo, L (Author) Other; Shah, A (Author) Other; Shlobin, O (Author) Other; Scholand, MB (Author) Other; Simms, R (Author) Other; Spiera, R (Author) Other; Steen, V (Author) Other; Veeraraghavan, S (Author) Other; Weigt, S (Author) Other

Journal

Title: Rheumatology

Vol. 63

Pages: 639-647

ISSN: 1462-0324

Publisher: Oxford University Press

Other information

Authenticus ID: P-018-6Y8

DOI: 10.1093/rheumatology/kead280

Abstract (EN): <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>To investigate the course of interstitial lung disease (ILD) and the effects of nintedanib in patients with limited cutaneous systemic sclerosis (lcSSc).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>In the SENSCIS trial, patients with SSc-ILD were randomized to receive nintedanib or placebo. Patients who completed the SENSCIS trial were eligible to enter SENSCIS-ON, in which all patients received open-label nintedanib.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Among 277 patients with lcSSc treated in the SENSCIS trial, the rate (s.e.) of decline in forced vital capacity (FVC; ml/year) over 52¿weeks was ¿74.5 (19.2) in the placebo group and ¿49.1 (19.8) in the nintedanib group (difference: 25.3 [95% CI ¿28.9, 79.6]). Among 249 patients with data at week 52, mean (s.e.) change in FVC at week 52 was ¿86.4 (21.1) ml in the placebo group and ¿39.1 (22.2) ml in the nintedanib group. Among 183 patients with lcSSc who participated in SENSCIS-ON and had data at week 52, mean (s.e.) change in FVC from baseline to week 52 of SENSCIS-ON was ¿41.5 (24.0) ml in patients who took placebo in the SENSCIS trial and initiated nintedanib in SENSCIS-ON and ¿45.1 (19.1) ml in patients who took nintedanib in the SENSCIS trial and continued it in SENSCIS-ON.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Patients with lcSSc may develop progressive fibrosing ILD. By targeting pulmonary fibrosis, nintedanib slows decline in lung function in patients with lcSSc and ILD.</jats:p> </jats:sec> <jats:sec> <jats:title>Trial registration</jats:title> <jats:p>ClinicalTrials.gov (https://clinicaltrials.gov), NCT02597933 and NCT03313180</jats:p> </jats:sec>

Language: English

Type (Professor's evaluation): Scientific