Radiogenomics: Lung Cancer-Related Genes Mutation Status Prediction

• Type: Article in International Conference Proceedings Book
• Date: 2019

Authors

Dias, C (Author) Other; Pinheiro, G (Author) Other; Cunha, A (Author) Other; Oliveira, HP (Author) FCUP

Conference proceedings International

Title: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Pages: 335-345

9th Iberian Conference on Pattern Recognition and Image Analysis, IbPRIA 2019

1 July 2019 through 4 July 2019

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00R-FA5

DOI: 10.1007/978-3-030-31321-0_29

Abstract (EN): Advances in genomics have driven to the recognition that tumours are populated by different minor subclones of malignant cells that control the way the tumour progresses. However, the spatial and temporal genomic heterogeneity of tumours has been a hurdle in clinical oncology. This is mainly because the standard methodology for genomic analysis is the biopsy, that besides being an invasive technique, it does not capture the entire tumour spatial state in a single exam. Radiographic medical imaging opens new opportunities for genomic analysis by providing full state visualisation of a tumour at a macroscopic level, in a non-invasive way. Having in mind that mutational testing of EGFR and KRAS is a routine in lung cancer treatment, it was studied whether clinical and imaging data are valuable for predicting EGFR and KRAS mutations in a cohort of NSCLC patients. A reliable predictive model was found for EGFR (AUC = 0.96) using both a Multi-layer Perceptron model and a Random Forest model but not for KRAS (AUC = 0.56). A feature importance analysis using Random Forest reported that the presence of emphysema and lung parenchymal features have the highest correlation with EGFR mutation status. This study opens new opportunities for radiogenomics on predicting molecular properties in a more readily available and non-invasive way. © 2019, Springer Nature Switzerland AG.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11