Biocellulose Membranes as Supports for Dermal Release of Lidocaine

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Eliane Trovatti (Author) Other; Nuno H C S Silva (Author) Other; Iola F Duarte (Author) Other; Catarina F Rosado (Author) Other; Isabel F Almeida (Author) FFUP; Paulo Costa (Author) FFUP; Carmen S R Freire (Author) Other; Armando J D Silvestre (Author) Other; Carlos Pascoal Neto (Author) Other

Journal

Title: Biomacromolecules

Vol. 12

Pages: 4162-4168

ISSN: 1525-7797

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 113 Citations

Scopus - 131 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-002-K04

DOI: 10.1021/bm201303r

Abstract (EN): Biocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTJR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7