Synthesis and Antitumor Evaluation of Benzopsoralen Analogues

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ana M. A. G. Oliveira (Author) Other; Ana M. F. Oliveira-Campos (Author) Other; Lígia M. Rodrigues (Author) Other; M. Manuela M. Raposo (Author) Other; Antonio E. H. Machado (Author) Other; M. São José Nascimento (Author) FFUP; N. Nazareth (Author) Other; Madalena Pinto (Author) FFUP

Journal

Title: Chemistry and Biodiversity

Vol. 4 No. 5

Pages: 980-990

ISSN: 1612-1872

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 7 Citations

ISI Web of Science

Scopus - 8 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-CQ2

Resumo (PT): The synthesis of five new tetracyclic benzopsoralen analogues, compounds 2–6, with 9H-xanthen-9-one or 9H-carbazole frameworks, is described. Their inhibitory effects on the growth of three human tumor cell lines (MCF-7, SF-268, and NCI-460) were evaluated, and discussed in terms of structure–activity relationship, taking into account both geometric and electronic features. Generally, the angular compounds showed significant biological activities, but the arrangement of functional groups also contributed to the overall activity. <br> <br> Keywords:Antitumor activity;Tumor growth inhibition;Benzopsoralen;Structure–activity relationship (SAR);Cytotoxic activity;Carbazoles;Xanthones <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790089/abstract"> Texto integral </a> <br> <br>

Abstract (EN): The synthesis of five new tetracyclic benzopsoralen analogues, compounds 2–6, with 9H-xanthen-9-one or 9H-carbazole frameworks, is described. Their inhibitory effects on the growth of three human tumor cell lines (MCF-7, SF-268, and NCI-460) were evaluated, and discussed in terms of structure–activity relationship, taking into account both geometric and electronic features. Generally, the angular compounds showed significant biological activities, but the arrangement of functional groups also contributed to the overall activity. <br> <br> Keywords:Antitumor activity;Tumor growth inhibition;Benzopsoralen;Structure–activity relationship (SAR);Cytotoxic activity;Carbazoles;Xanthones <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790089/abstract"> Full text </a> <br> <br>

Language: English

Type (Professor's evaluation): Scientific