Erythrocyte changes in preeclampsia: relationship between maternal and cord blood erythrocyte damage

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Cristina Catarino (Author) FFUP; Irene Rebelo (Author) FFUP; Luis Belo (Author) FFUP; Petronila Rocha Pereira (Author) Other; Susana Rocha (Author) FFUP; Elisabeth Bayer Castro (Author) Other; Belmiro Patricio (Author) Other; Alexandre Quintanilha (Author) ICBAS; Alice Santos Silva (Author) FFUP

Journal

Title: Journal of Perinatal Medicine

Vol. 37 No. 1

Pages: 19-27

ISSN: 0300-5577

Publisher: Walter De Gruyter

Indexing

ISI Web of Knowledge - 13 Citations

ISI Web of Science

Scopus - 12 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

CORDIS: Health sciences

Other information

Authenticus ID: P-003-R2D

DOI: 10.1515/jpm.2009.007

Resumo (PT): Our aim was to evaluate red blood cell (RBC) changes in normal and preeclamptic cases, and to assess the relationship between maternal and umbilical cord blood (UCB) changes. We evaluated markers of RBC damage: membrane bound hemoglobin (MBH) and band 3 profile – high molecular weight aggregates (HMWSAg), monomer and proteolytic fragments. RBCs are marked for removal by a rise in MBH and in HMWAg. Preeclamptic mothers had significantly higher MBH, RBC count, hemoglobin, hematocrit, reticulocytes and reticulocyte production index (RPI). In UCB from newborns of preeclamptic mothers, we found similar HMWAg, RBC count, hemoglobin and hematocrit; significantly higher MBH, mean cell hemoglobin concentration, mean cell volume, RPI and reticulocyte count. Maternal MBH and HMWAg values were positively and significantly correlated with MBH and HMWAg values in UCB, in normal as well as in preeclamptic pregnancies; in preeclampsia, a significant positive correlation between UCB and maternal bilirubin, and between RPI and proteinuria were found. We conclude that markers of RBC damage/production are altered in preeclampsia, in both UCB and maternal circulation. Our data show similarities between UCB and maternal RBC changes, as suggested by the correlations of markers of RBC damage. <br> <br> <a target="_blank" href="http://ejournals.ebsco.com/Article.asp?ContributionID=17616506 "> Texto integral </a> <br> <br>

Abstract (EN): Our aim was to evaluate red blood cell (RBC) changes in normal and preeclamptic cases, and to assess the relationship between maternal and umbilical cord blood (UCB) changes. We evaluated markers of RBC damage: membrane bound hemoglobin (MBH) and band 3 profile-high molecular weight aggregates (HMWSAg), monomer and proteolytic fragments. RBCs are marked for removal by a rise in MBH and in HMWAg. Preeclamptic mothers had significantly higher MBH, RBC count, hemoglobin, hematocrit, reticulocytes and reticulocyte production index (RPI). In UCB from newborns of preeclamptic mothers, we found similar HMWAg, RBC count, hemoglobin and hematocrit; significantly higher MBH, mean cell hemoglobin concentration, mean cell volume, RPI and reticulocyte count. Maternal MBH and HMWAg values were positively and significantly correlated with MBH and HMWAg values in UCB, in normal as well as in preeclamptic pregnancies; in preeclampsia, a significant positive correlation between UCB and maternal bilirubin, and between RPI and proteinuria were found. We conclude that markers of RBC damage/production are altered in preeclampsia, in both UCB and maternal circulation. Our data show similarities between UCB and maternal RBC changes, as suggested by the correlations of markers of RBC damage.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9