Sequential injection determination of meloxicam in pharmaceutical formulations with spectrophotometric detection

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Vandera Vasiliki (Author) Other; Paula C A G Pinto (Author) FFUP; Lucia L M F S Saraiva (Coordinator) FFUP; Jose L F C Lima (Author) FFUP

Journal

Title: Canadian Journal of Analytical Sciences and Spectroscopy

Vol. 52 No. 6

Pages: 351-358

ISSN: 1205-6685

Publisher: Spectroscopy Society of Canada

Indexing

ISI Web of Knowledge - 1 Citation

ISI Web of Science

Scopus - 4 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-CNQ

Resumo (PT): A fast and robust sequential injection analysis (SIA) methodology for routine control determination of meloxicam in solid pharmaceutical formulations is presented. The developed automatic procedure is based on the reaction of meloxicam with Fe (III) and ferricyanide, to form a green product with maximum absorption at 770 nm. Linear calibration plots were obtained for meloxicam concentrations up to 7×10-5 mol L-1, with a detection limit of about 2.7×10-5 mol L-1. The developed methodology was applied to meloxicam determination in solid pharmaceutical formulations and the obtained results complied with those furnished by a HPLC comparison procedure. The automatic methodology exhibited good reproducibility (RSD < 0.8%, n = 15) and the sampling rate was approximately 40 samples per hour. No interference was found from the excipients usually used in solid pharmaceutical formulations. <br> <br> Keywords: SIA, meloxicam, pharmaceutical formulations <br>

Abstract (EN): A fast and robust sequential injection analysis (SIA) methodology for routine control determination of meloxicam in solid pharmaceutical formulations is presented. The developed automatic procedure is based on the reaction of meloxicam with Fe (III) and ferricyanide, to form a green product with maximum absorption at 770 nm. Linear calibration plots were obtained for meloxicam concentrations up to 7 x 10(-5) mol L-1, with a detection limit of about 2.7 x 10(-5) mol L-1. The developed methodology was applied to meloxicam determination in solid pharmaceutical formulations and the obtained results complied with those furnished by a HPLC comparison procedure. The automatic methodology exhibited good reproducibility (RSD < 0.8%, n = 15) and the sampling rate was approximately 40 samples per hour. No interference was found from the excipients usually used in solid pharmaceutical formulations.

Language: English

Type (Professor's evaluation): Scientific

Notes: autor para correspondência