Resumo (PT):
A fast and robust sequential injection analysis
(SIA) methodology for routine control determination
of meloxicam in solid pharmaceutical formulations
is presented. The developed automatic procedure is
based on the reaction of meloxicam with Fe (III) and
ferricyanide, to form a green product with maximum
absorption at 770 nm. Linear calibration plots were
obtained for meloxicam concentrations up to 7×10-5
mol L-1, with a detection limit of about 2.7×10-5 mol L-1.
The developed methodology was applied to meloxicam
determination in solid pharmaceutical formulations
and the obtained results complied with those furnished
by a HPLC comparison procedure. The automatic
methodology exhibited good reproducibility (RSD <
0.8%, n = 15) and the sampling rate was approximately
40 samples per hour. No interference was found from
the excipients usually used in solid pharmaceutical
formulations.
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Keywords: SIA, meloxicam, pharmaceutical formulations
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Abstract (EN):
A fast and robust sequential injection analysis (SIA) methodology for routine control determination of meloxicam in solid pharmaceutical formulations is presented. The developed automatic procedure is based on the reaction of meloxicam with Fe (III) and ferricyanide, to form a green product with maximum absorption at 770 nm. Linear calibration plots were obtained for meloxicam concentrations up to 7 x 10(-5) mol L-1, with a detection limit of about 2.7 x 10(-5) mol L-1. The developed methodology was applied to meloxicam determination in solid pharmaceutical formulations and the obtained results complied with those furnished by a HPLC comparison procedure. The automatic methodology exhibited good reproducibility (RSD < 0.8%, n = 15) and the sampling rate was approximately 40 samples per hour. No interference was found from the excipients usually used in solid pharmaceutical formulations.
Language:
English
Type (Professor's evaluation):
Scientific
Notes:
autor para correspondência