Effect of anti-inflammatory drugs in phosphatidylcholine membranes: A fluorescence and calorimetric study

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Lucio, M (Author) FFUP; Nunes, C (Author) Other; Gaspar, D (Author) Other; Golebska, K (Author) Other; Wisniewski, M (Author) Other; Lima, JLFC (Author) FFUP; Brezesinski, G (Author) Other; Reis, S (Author) FFUP

Journal

Title: Chemical Physics Letters

Vol. 471 No. 4

Pages: 300-309

ISSN: 0009-2614

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 35 Citations

ISI Web of Science

Scopus - 40 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-003-MEP

DOI: 10.1016/j.cplett.2009.02.047

Resumo (PT): NSAIDs are the most prescribed drugs for inflammation, and their use is associated with severe gastrointestinal toxicity. This work focuses on the interaction of NSAIDs with membranes, specifically, on their ability to affect the lipid dynamic properties, since this may explain the compromising effects on the integrity of gastric barrier. Studies covered the assessment of drug–membrane/water partition coefficient and location by derivative spectroscopy and fluorescence quenching techniques and effects on membrane biophysics by DSC. Results indicate that the NSAIDs studied have membrane destabilizing effects, which could be transposed to similar effects in the stomach’s phospholipid layer justifying their toxicity <br> <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TFN-4VNH43D-F&_user=2460038&_coverDate=03%2F26%2F2009&_rdoc=25&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235231%232009%23995289995%23989051%23FLA%23display%23Volume)&_cdi=5231&_sort=d&_docanchor=&_ct=31&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=4e96fd670ec6043993c99c7f1f8e3d39"> Texto integral</a> <br> <br>

Abstract (EN): NSAIDs are the most prescribed drugs for inflammation, and their use is associated with severe gastrointestinal toxicity. This work focuses on the interaction of NSAIDs with membranes, specifically, on their ability to affect the lipid dynamic properties, since this may explain the compromising effects on the integrity of gastric barrier. Studies covered the assessment of drug-membrane/water partition coefficient and location by derivative spectroscopy and fluorescence quenching techniques and effects on membrane biophysics by DSC. Results indicate that the NSAIDs studied have membrane destabilizing effects, which could be transposed to similar effects in the stomach's phospholipid layer justifying their toxicity. (C) 2009 Published by Elsevier B. V.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10