Serum levels of VEGF and TNF-α and their association with C-reactive protein in patients with endometriosis

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Pedro Xavier (Author) Other; Luís Belo (Author) FFUP; Jorge Beires (Author) Other; Irene Rebelo (Author) FFUP; José Martinez-de-Oliveira (Author) Other; Nuno Lunet (Author) Other; Henrique Barros (Author) Other

Journal

Title: Archives of Gynecology and Obstetrics

Vol. 273 No. 4

Pages: 227-231

ISSN: 0932-0067

Publisher: Springer Nature

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Resumo (PT): Objective: To compare serum levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) throughout the menstrual cycle in women with and without endometriosis and to quantify the association between these serum markers. Methods: Twenty five endometriosis patients (ASRM stage III–IV) and 13 controls were followed through one menstrual cycle. VEGF, TNF-α and CRP concentrations were measured with enzyme-linked immunosorbent assay in each of the four cycle phases (early and late proliferative and early and late secretory). Non-parametric methods and Pearson’s correlation coefficients were used for statistical analysis. Results: Increased serum levels of VEGF in secretory phases and of TNF-α in all cycle phases were observed. A positive correlation between CRP and VEGF was found in endometriosis patients but not in controls. Conclusions: Our results suggest that excessive systemic angiogenic activity is a feature of patients with endometriosis. <br> <br> Keywords VEGF - TNF-α - C-reactive protein - Menstrual cycle - Endometriosis <br> <a target="_blank" href="http://www.springerlink.com/content/b7t64p7467742113/?p=f82149724207423c81f7a5d7da240d66&pi=6"> Texto integral</a> <br> <br>

Abstract (EN): Objective: To compare serum levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) throughout the menstrual cycle in women with and without endometriosis and to quantify the association between these serum markers. Methods: Twenty five endometriosis patients (ASRM stage III–IV) and 13 controls were followed through one menstrual cycle. VEGF, TNF-α and CRP concentrations were measured with enzyme-linked immunosorbent assay in each of the four cycle phases (early and late proliferative and early and late secretory). Non-parametric methods and Pearson’s correlation coefficients were used for statistical analysis. Results: Increased serum levels of VEGF in secretory phases and of TNF-α in all cycle phases were observed. A positive correlation between CRP and VEGF was found in endometriosis patients but not in controls. Conclusions: Our results suggest that excessive systemic angiogenic activity is a feature of patients with endometriosis. <br> <br> Keywords VEGF - TNF-α - C-reactive protein - Menstrual cycle - Endometriosis <br> <a target="_blank" href="http://www.springerlink.com/content/b7t64p7467742113/?p=f82149724207423c81f7a5d7da240d66&pi=6"> Full text </a> <br> <br>

Language: Portuguese

Type (Professor's evaluation): Scientific