Fetal and maternal angiogenic/anti-angiogenic factors in normal and preeclamptic pregnancy

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Cristina Catarino (Author) FFUP; Irene Rebelo (Author) FFUP; Luis Belo (Author) FFUP; Susana Rocha (Author) FFUP; Elisabeth B Castro (Author) Other; Belmiro Patricio (Author) Other; Alexandre Quintanilha (Author) ICBAS; Alice Santos Silva (Author) FFUP

Journal

Title: Growth Factors

Vol. 27 No. 6

Pages: 345-351

ISSN: 0897-7194

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 24 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

CORDIS: Health sciences

Other information

Authenticus ID: P-003-DXP

DOI: 10.3109/08977190903184670

Resumo (PT): Few studies evaluated angiogenic/anti-angiogenic factors and endothelial (dys)function in both maternal and umbilical cord blood (UCB) in preeclampsia (PE). We aimed to clarify the role of placental growth factor (PlGF), vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 1 (VEGFR-1) and tissue plasminogen activator (tPA), by evaluating them in maternal and UCB in 42 normal and 46 preeclamptic (PEc) cases. In PE, maternal and UCB PlGF were significantly lower; maternal VEGF, sVEGFR-1 and tPA were significantly higher. In UCB, sVEGFR-1 and tPA were significantly higher in PEc cases, while VEGF and PlGF were significantly lower. A significant correlation between maternal and UCB sVEGFR-1, and between sVEGFR-1 and tPA both in maternal and UCB, was observed in PEc cases. In maternal and UCB circulation in PE, a close interaction seems to exist between endothelial dysfunction and angiogenesis disturbance, and sVEGFR-1 seems to play a central role in those disturbances <br> <br>

Abstract (EN): Few studies evaluated angiogenic/anti-angiogenic factors and endothelial (dys) function in both maternal and umbilical cord blood (UCB) in preeclampsia (PE). We aimed to clarify the role of placental growth factor (PlGF), vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 1 (VEGFR-1) and tissue plasminogen activator (tPA), by evaluating them in maternal and UCB in 42 normal and 46 preeclamptic (PEc) cases. In PE, maternal and UCB PlGF were significantly lower; maternal VEGF, sVEGFR-1 and tPA were significantly higher. In UCB, sVEGFR-1 and tPA were significantly higher in PEc cases, while VEGF and PlGF were significantly lower. A significant correlation between maternal and UCB sVEGFR-1, and between sVEGFR-1 and tPA both in maternal and UCB, was observed in PEc cases. In maternal and UCB circulation in PE, a close interaction seems to exist between endothelial dysfunction and angiogenesis disturbance, and sVEGFR-1 seems to play a central role in those disturbances.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7