Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Hypertension Induced by Immunosuppressive Drugs: A Comparative Analysis Between Sirolimus and Cyclosporine
Publication

Publications

Hypertension Induced by Immunosuppressive Drugs: A Comparative Analysis Between Sirolimus and Cyclosporine

Title
Hypertension Induced by Immunosuppressive Drugs: A Comparative Analysis Between Sirolimus and Cyclosporine
Type
Article in International Scientific Journal
Year
2009
Authors
Reis, F
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. View Authenticus page Without ORCID
Parada, B
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Teixeira T de Lemos
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Garrido, P
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Dias, A
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Piloto, N
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Baptista, S
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Sereno, J
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Eufrasio, P
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Costa, E
(Author)
FFUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Rocha Pereira, P
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Santos Silva, A
(Author)
FFUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Figueiredo, A
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Mota, A
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Teixeira, F
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. View Authenticus page Without ORCID
Journal
Vol. 41 No. 3
Pages: 868-873
ISSN: 0041-1345
Publisher: Elsevier
Indexing
Scientific classification
FOS: Medical and Health sciences > Basic medicine
CORDIS: Health sciences
Other information
Authenticus ID: P-003-MDC
Resumo (PT): The purpose of this study was to compare the effects of sirolimus (SRL) vs cyclosporine (CsA) concerning the cardiovascular mechanisms hypothetically contributing to hypertension development. Three rat groups were studied: control (vehicle), CsA (5 mg/kg/d), and SRL (1 mg/kg/d). The following parameters were evaluated after 7 weeks of treatment: blood pressured (BP) and heart rate (HR; tail cuff), lipid profile, hematology, plasma and platelet 5-HT and catecholamines (HPLC-ECD), and oxidative equilibrium (serum malondialdehyde [MDA] and total antioxidant status [TAS]). Systolic (SBP) and diastolic blood pressure (DBP) values were higher (P < .001) in both the CsA (146.2 ± 4.5 and 124.9 ± 4.5 mm Hg) and SRL (148.9 ± 4.8 and 126.4 ± 6.0 mm Hg) groups vs the controls (115.9 ± 3.3 and 99.1 ± 2.0 mm Hg). However, HR values were elevated in CsA but not SRL animals. The dyslipidemic pattern of CsA was even more enhanced in the SRL group, with significantly higher low-density lipoprotein cholesterol (LDL-c) and triglyceride (TG) levels vs CsA (P < .05); red blood cells, hematocrit, hemoglobin concentration, mean platelet volume, and platelet distribution width were significantly (P < .05) higher in the SRL vs CsA group. The pro-oxidative profile (increased MDA/TAS) in the CsA group was not reproduced in the SRL cohort. While plasma and platelet 5-HT were elevated in SRL rats, catecholamine content was higher in CsA animals. In conclusion, this study demonstrated that CsA and SRL produce identical hypertensive effects. However, while CsA promotes oxidative stress and sympathetic activation, SRL mainly interferes with lipid profile and hematological parameters. Thus, the hypertensive effects of CsA, a calcineurin inhibitor, and of SRL, an mTOR inhibitor, are associated with impairment of distinct cardiovascular pathways. <br> <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VJ0-4W39NT4-X&_user=2460038&_coverDate=04%2F30%2F2009&_rdoc=26&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236080%232009%23999589996%231055057%23FLA%23display%23Volume)&_cdi=6080&_sort=d&_docanchor=&_ct=81&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=973be6aa2baac0b1671d6fcb1316435d "> Texto integral </a> <br> <bR>
Abstract (EN): The purpose of this study was to compare the effects of sirolimus (SRL) vs cyclosporine (CSA) concerning the cardiovascular mechanisms hypothetically contributing to hypertension development. Three rat groups were studied: control (vehicle), CsA (5 mg/kg/d), and SRL (I mg/kg/d). The following parameters were evaluated after 7 weeks of treatment: blood pressured (BP) and heart rate (HR; tail cuff), lipid profile, hematology, plasma and platelet 5-HT and catecholamines (HPLC-ECD), and oxidative equilibrium (serum malondialdehyde [MDA] and total antioxidant status [TAS]). Systolic (SBP) and diastolic blood pressure (DBP) values were higher (P <.001) in both the CsA (146.2 +/- 4.5 and 124.9 +/- 4.5 mm Hg) and SRL (148.9 +/- 4.8 and 126.4 +/- 6.0 mm Hg) groups vs the controls (115.9 +/- 3.3 and 99.1 +/- 2.0 mm Hg). However, HR values were elevated in CsA but not SRL animals. The dyslipidemic pattern of CsA was even more enhanced in the SRL group, with significantly higher low-density lipoprotein cholesterol (LDL-c) and triglyceride (TG) levels vs CsA (P <.05); red blood cells, hematocrit, hemoglobin concentration, mean platelet volume, and platelet distribution width were significantly (P <.05) higher in the SRL vs CsA group. The pro-oxidative profile (increased MDA/TAS) in the CsA group was not reproduced in the SRL cohort. While plasma and platelet 5-HT were elevated in SRL rats, catecholamine content was higher in CsA animals. In conclusion, this study demonstrated that CsA and SRL produce identical hypertensive effects. However, while CsA promotes oxidative stress and sympathetic activation, SRL mainly interferes with lipid profile and hematological parameters. Thus, the hypertensive effects of CsA, a calcineurin inhibitor, and of SRL, an mTOR inhibitor, are associated with impairment of distinct cardiovascular pathways.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 6
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same scientific areas

Therapeutic potential of neuregulin-1 in cardiovascular disease (2013)
Another Publication in an International Scientific Journal
Pedro Mendes Ferreira; Gilles W De Keulenaer; Adelino F Leite Moreira; Carmen Bras Silva
Linezolid-Resistant Staphylococcus epidermidis, Portugal, 2012 (2014)
Another Publication in an International Scientific Journal
Mariana Barros; Raquel Branquinho; Filipa Grosso; Luisa Peixe; Carla Novais
Metabolism of the designer drug 4-methylthioamphetamine (4-MTA) by hepatocytes from man, monkey, dog, rabbit, rat and mouse: A comparative study (2004)
Other Publications
Bastos, ML; Carmo, H; Hengstler, JG; de Boer, D; Ringel, M; Carvalho, F; Fernandes, E; Remiao, F; Reys, L; Oesch, F
Expression of angiogenic factors in solid cell nests (ultimobranchial remnants) of the thyroid gland (2008)
Other Publications
Cameselle Teijeiro, J; Abdulkader, I; Alfonsin Barreiro, M; Reyes Santias, R; Soares, P; Forteza, J; Sobrinho Simoes, M
Determination of formic acid in urine of workers occupationally exposed to formaldehyde (2010)
Other Publications
Mautempo, C; Bastos, MDL; Carvalho, F; Remiao, F; Carmo, H; Guedes De Pinho, P

See all (56)

Of the same journal

Spleen-Restricted Posttransplant Lymphoproliferative Disorder in the First Year After Kidney Transplant - A Case Report (2022)
Another Publication in an International Scientific Journal
Rodrigues, AC; Fernandes, S; Bustorff, M; Nunes, AT; Ferreira, I; Tavares, I; Rocha, A; Carneiro, A; Sampaio, SN
Renal Transplantation in HIV-Infected Patients: The First Portuguese Review (2015)
Another Publication in an International Scientific Journal
Querido, S; Machado, D; Silva, C; Nolasco, F; Nunes, A; Sampaio, S; Cruz, P; Oliveira, C; Weigert, A
Organ donor viral screening and its implications in transplantation; An overview (2000)
Another Publication in an International Scientific Journal
Sarmento A; Freitas, F; Tavares, AP; Machado, D
Wilson's disease: Challenging diagnosis, management, and liver transplantation timing (2000)
Article in International Scientific Journal
Macedo G; Maia, JC; Gomes, A; Amil, J; Fernandes, N; Carneiro F; Teixeira, A; Ribeiro, T
Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients (2021)
Article in International Scientific Journal
Silvano, J; Ferreira, F; Bustorff, M; Nunes, AT; Tavares, I; Simoes, JS; Ramos, A; Cardoso, MJ; Sampaio, S; Pestana M

See all (46)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-10 at 04:04:53 | Privacy Policy | Personal Data Protection Policy | Whistleblowing