Sensitive sequential injection determination of naproxen based on interaction with β-cyclodextrin

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Eftychia-Pavlina Zisiou (Author) Other; Paula C.A.G. Pinto (Author) FFUP; M. Lúcia M.F.S. Saraiva (Author) FFUP; Christophe Siquet (Author) Other; José L.F.C. Lima (Author) FFUP

Journal

Title: Talanta

Vol. 68 No. 2

Pages: 226-230

ISSN: 0039-9140

Publisher: Elsevier

Indexing

ISI Web of Science

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences

Other information

Resumo (PT): A sensitive sequential injection analysis (SIA) methodology for the fluorimetric determination of naproxen is proposed. The developed automatic analytical procedure is based on the complexation of naproxen with β-cyclodextrin (β-CD) yielding an enhanced fluorimetric signal (λex = 280 nm, λem = 356 nm). Linear calibration plots were obtained for naproxen concentrations up to 1 × 10−5 mol l−1. The developed methodology exhibited a good precision, with a R.S.D. < 2.1% (n = 15). The detection limit of the determination was 1.9 × 10−7 mol l−1 with a sampling rate of about 70 h−1. The automatic method was applied to the determination of naproxen in pharmaceutical formulations. The obtained results were compared with those furnished by the reference procedure and the relative deviations were lower than 3.6%. No interference was found from the excipients usually used in solid pharmaceutical formulations. <br> <br> Keywords: SIA; Fluorescence; β-Cyclodextrin; Naproxen <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6THP-4GX6HTW-1&_user=2460038&_coverDate=12%2F15%2F2005&_rdoc=13&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235288%232005%23999319997%23610440%23FLA%23display%23Volume)&_cdi=5288&_sort=d&_docanchor=&_ct=51&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=1f0c87110eca74ededdebb718375bc03"> Texto integral</a> <br> <br>

Abstract (EN): A sensitive sequential injection analysis (SIA) methodology for the fluorimetric determination of naproxen is proposed. The developed automatic analytical procedure is based on the complexation of naproxen with β-cyclodextrin (β-CD) yielding an enhanced fluorimetric signal (λex = 280 nm, λem = 356 nm). Linear calibration plots were obtained for naproxen concentrations up to 1 × 10−5 mol l−1. The developed methodology exhibited a good precision, with a R.S.D. < 2.1% (n = 15). The detection limit of the determination was 1.9 × 10−7 mol l−1 with a sampling rate of about 70 h−1. The automatic method was applied to the determination of naproxen in pharmaceutical formulations. The obtained results were compared with those furnished by the reference procedure and the relative deviations were lower than 3.6%. No interference was found from the excipients usually used in solid pharmaceutical formulations. <br> <br> Keywords: SIA; Fluorescence; β-Cyclodextrin; Naproxen <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6THP-4GX6HTW-1&_user=2460038&_coverDate=12%2F15%2F2005&_rdoc=13&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235288%232005%23999319997%23610440%23FLA%23display%23Volume)&_cdi=5288&_sort=d&_docanchor=&_ct=51&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=1f0c87110eca74ededdebb718375bc03"> Full text</a> <br> <br>

Language: Portuguese

Type (Professor's evaluation): Scientific