Sequential injection spectrophotometric determination of metoclopramide in pharmaceutical preparations

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ieda de Souza Silva (Author) Other; Lucia L M F S Saraiva (Author) FFUP; Joao L M Santos (Author) FFUP; Jose L F C Lima (Author) FFUP

Journal

Title: Spectroscopy Letters

Vol. 40 No. 1

Pages: 51-61

ISSN: 0038-7010

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 8 Citations

ISI Web of Science

Scopus - 12 Citations

Scientific classification

FOS: Natural sciences > Physical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-ENE

DOI: 10.1080/00387010601093778

Resumo (PT): In this work, a spectrophotometric methodology for the determination of metoclopramide in pharmaceutical preparations is proposed. The approach was based on the reaction of metoclopramide with Folin-Ciocalteu reagent and was implemented on a sequential injection analysis automated flow system. An in-line mixing chamber was used to promote reaction zone homogenization, to increase reaction time, and to attenuate the high refractive index gradient generated by the utilization of concentrated solutions, thus enabling the minimization of the Schlieren effect. Linear calibration plots for metoclopramide concentrations up to 100 mg L-1 were obtained, with good precision (RSD<3%, n=10). The detection limit was 2.0 mg L-1 and the quantification limit was 6.8 mg L-1. 1 The authors were invited to contribute this paper to a special issue of the journal entitled “Spectroscopy and Automation”. This special issue was organized by Miguel de la Guardia, Professor of Analytical Chemistry at Valencia University, Spain. The special issue was published in volume 39, issue 6. <br> <br> Keywords: Folin-Ciocalteu reagent; metoclopramide; sequential injection analysis; spectrophotometry <br> <a target="_blank" href="http://www.informaworld.com/smpp/content~db=all~content=a771839356"> Texto integral</a> <br> <br>

Abstract (EN): In this work, a spectrophotometric methodology for the determination of metoclopramide in pharmaceutical preparations is proposed. The approach was based on the reaction of metoclopramide with Folin-Ciocalteu reagent and was implemented on a sequential injection analysis automated flow system. An in-line mixing chamber was used to promote reaction zone homogenization, to increase reaction time, and to attenuate the high refractive index gradient generated by the utilization of concentrated solutions, thus enabling the minimization of the Schlieren effect. Linear calibration plots for metoclopramide concentrations up to 100 mg L-1 were obtained, with good precision (RSD < 3%, n = 10). The detection limit was 2.0 mg L-1 and the quantification limit was 6.8 mg L-1.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11