Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: beta-Cyclodextrin complex

• Type: Article in International Scientific Journal
• Date: 2011

Authors

salustio, pj (Author) Other; cabral-marques, hm (Author) Other; costa, pc (Author) FFUP; pinto, jf (Author) Other

Journal

Title: European Journal of Pharmaceutics and Biopharmaceutics

Vol. 78

Pages: 58-66

ISSN: 0939-6411

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 22 Citations

Other information

Authenticus ID: P-002-RWQ

DOI: 10.1016/j.ejpb.2010.12.022

Abstract (EN): Mixtures containing ibuprofen (IB) complexed with beta-cyclodextrin (beta CD) obtained by two complexation methods [suspension/solution (with water removed by air stream, spray- and freeze-drying) and kneading technique] were processed into pharmaceutical dosage forms (minitablets and capsules). Powders (IB, beta CD and IB beta CD) were characterized for moisture content, densities (true and bulk), angle of repose and Carr's index, X-ray and NMR. From physical mixtures and IB beta CD complexes without other excipients were prepared 2.5-mm-diameter minitablets and capsules. Minitablets were characterized for the energy of compaction, tensile strength, friability, density and IB release (at pH 1.0 and 7.2), whereby capsules were characterized for IB release. The results from the release of IB were analyzed using different parameters, namely, the similarity factor (f(2)), the dissolution efficiency (DE) and the amounts released at a certain time (30,60 and 180 min) and compared statistically (alpha = 0.05). The release of IB from the minitablets showed no dependency on the amount of water used in the formation of the complexes. Differences were due to the compaction force used or the presence of a shell for the capsules. The differences observed were mostly due to the characteristics of the particles (dependent on the method considered on the formation of the complexes) and neither to the dosage form nor to the complex of the IB.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9