Purinergic receptors in the splanchnic circulation

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Manuela Morato (Author) FFUP; Teresa Sousa (Author) FFUP; António Albino-Teixeira (Author) Other

Journal

Title: Purinergic Signalling

Vol. 4 No. 3

Pages: 267-285

ISSN: 1573-9538

Publisher: Springer Nature

Indexing

ISI Web of Science

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences

Other information

Resumo (PT): There is considerable evidence that purines are vasoactive molecules involved in the regulation of blood flow. Adenosine is a well known vasodilator that also acts as a modulator of the response to other vasoactive substances. Adenosine exerts its effects by interacting with adenosine receptors. These are metabotropic G-protein coupled receptors and include four subtypes, A1, A2A, A2B and A3. Adenosine triphosphate (ATP) is a co-transmitter in vascular neuroeffector junctions and is known to activate two distinct types of P2 receptors, P2X (ionotropic) and P2Y (metabotropic). ATP can exert either vasoconstrictive or vasorelaxant effects, depending on the P2 receptor subtype involved. Splanchnic vascular beds are of particular interest, as they receive a large fraction of the cardiac output. This review focus on purinergic receptors role in the splanchnic vasomotor control. Here, we give an overview on the distribution and diversity of effects of purinergic receptors in splanchnic vessels. Pre- and post-junctional receptormediated responses are summarized. Attention is also given to the interactions between purinergic receptors and other receptors in the splanchnic circulation. <br> <br> Keywords: Adenosine receptors, purinergic, P2X receptors, P2Y receptors, Splanchnic vasculature <br> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486341/?report=abstract"> Texto integral </a> <br> <br>

Abstract (EN): There is considerable evidence that purines are vasoactive molecules involved in the regulation of blood flow. Adenosine is a well known vasodilator that also acts as a modulator of the response to other vasoactive substances. Adenosine exerts its effects by interacting with adenosine receptors. These are metabotropic G-protein coupled receptors and include four subtypes, A1, A2A, A2B and A3. Adenosine triphosphate (ATP) is a co-transmitter in vascular neuroeffector junctions and is known to activate two distinct types of P2 receptors, P2X (ionotropic) and P2Y (metabotropic). ATP can exert either vasoconstrictive or vasorelaxant effects, depending on the P2 receptor subtype involved. Splanchnic vascular beds are of particular interest, as they receive a large fraction of the cardiac output. This review focus on purinergic receptors role in the splanchnic vasomotor control. Here, we give an overview on the distribution and diversity of effects of purinergic receptors in splanchnic vessels. Pre- and post-junctional receptormediated responses are summarized. Attention is also given to the interactions between purinergic receptors and other receptors in the splanchnic circulation. <br> <br> Keywords: Adenosine receptors, purinergic, P2X receptors, P2Y receptors, Splanchnic vasculature <br> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486341/?report=abstract"> Full text </a> <br> <br>

Language: English

Type (Professor's evaluation): Scientific