The natural prenylated flavone artelastin is an inhibitor of ROS and NO production

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Cerqueira, F (Author) Other; Cidade, H (Author) FFUP; van Ufford, L (Author) Other; Beukelman, C (Author) Other; Kijjoa, A (Author) ICBAS; Nascimento, MSJ (Author) FFUP

Journal

Title: International Immunopharmacology

Vol. 8 No. 13

Pages: 597-602

ISSN: 1567-5769

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 13 Citations

ISI Web of Science

Scopus - 14 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences

Other information

Authenticus ID: P-004-0GF

DOI: 10.1016/j.intimp.2007.12.013

Resumo (PT): Artelastin, a prenylated flavone previously isolated from Artocarpus elasticus, was evaluated for its effect on the production of reactive oxygen species (ROS) by human polymorphonuclear neutrophils (PMNs) and nitric oxide (NO) by J774 murine macrophage cell line. Artelastin showed to be an inhibitor of ROS production due to a strong O2− scavenging activity. No effect was observed on the activity of myeloperoxidase (MPO). Artelastin showed also to be an inhibitor of NO production without NO scavenging activity. This flavone seems to interfere with the expression of the inducible nitric oxide synthase (iNOS) immediately after LPS-IFNγ–macrophage stimulation. <br> <br> Keywords: Artelastin;; Artocarpus elasticus;; Nitric oxide;; Prenylated flavones;; Reactive oxygen species <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7N-4RKMB53-1&_user=2460038&_coverDate=04%2F30%2F2008&_rdoc=12&_fmt=high&_orig=browse&_origin=browse&_zone=rslt_list_item&_srch=doc-info(%23toc%236631%232008%23999919995%23682374%23FLA%23display%23Volume)&_cdi=6631&_sort=d&_docanchor=&_ct=13&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=400d20fdb1fbe6bcebacab7d83cb5ade&searchtype=a"> Texto integral </a> <br> <br>

Abstract (EN): Artelastin, a prenylated flavone previously isolated from Artocarpus elasticus, was evaluated for its effect on the production of reactive oxygen species (ROS) by human polymorphonuclear neutrophils (PMNs) and nitric oxide (NO) by J774 murine macrophage cell tine. Artetastin showed to be an inhibitor of ROS production due to a strong O-2(-) scavenging activity. No effect was observed on the activity of myeloperoxidase (MPO). Artetastin showed also to be an inhibitor of NO production without NO scavenging activity. This flavone seems to interfere with the expression of the inducible nitric oxide synthase (iNOS) immediately after LPS-IFN gamma-macrophage stimulation. (c) 2008 Published by Elsevier B. V.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6