Fully automated spectrophotometric method for the determination of buspirone in pharmaceutical preparations

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Marta F T Ribeiro (Author) Other; Joao L M Santos (Author) FFUP; Jose L F C Lima (Author) FFUP; Ana C B Dias (Author) Other; Elias A G Zagatto (Author) Other

Journal

Title: Analytical Letters

Vol. 39 No. 11

Pages: 2243-2253

ISSN: 0003-2719

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 5 Citations

ISI Web of Science

Scopus - 7 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-P3J

DOI: 10.1080/00032710600755348

Resumo (PT): A fully automated kinetic method for the spectrophotometric determination of buspirone in pharmaceutical preparations is proposed. The analytical system was implemented by using multiple solenoid micropumps for sample and reagents insertion, which led to improved operational simplicity and low reagent consumption. A three-way solenoid valve enabled the establishment of two parallel reactors and the exploitation of the fixed time approach for differential kinetics. Linear calibration plots for buspirone concentrations of up to 60mgL21 were obtained, with a detection limit of 2.8mgL21. The sampling rate was about 55 samples per hour. <br> <br> Keywords: Multipumping flow analysis, spectrophotometry, buspirone, Folin- Ciocalteu reagent <br> <a target="_blank" href="http://www.informaworld.com/smpp/content~db=all~content=a749252619 "> Texto integral </a> <br> <br>

Abstract (EN): A fully automated kinetic method for the spectrophotometric determination of buspirone in pharmaceutical preparations is proposed. The analytical system was implemented by using multiple solenoid micropumps for sample and reagents insertion, which led to improved operational simplicity and low reagent consumption. A three-way solenoid valve enabled the establishment of two parallel reactors and the exploitation of the fixed time approach for differential kinetics. Linear calibration plots for buspirone concentrations of up to 60 mgL(-1) were obtained, with a detection limit of 2.8 mgL(-1). The sampling rate was about 55 samples per hour.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11