Tetracycline Potentiometric Sensor Based on Cyclodextrin for Pharmaceuticals and Waste Water Analysis

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Claudia O Cunha (Author) Other; Rita C R Silva (Author) Other; Celia G Amorim (Author) FFUP; Severino A Junior (Author) Other; Alberto N Araujo (Author) FFUP; Maria C B S M Montenegro (Author) FFUP; Valdinete L Silva (Author) Other

Journal

Title: Electroanalysis

Vol. 22 No. 24

Pages: 2967-2972

ISSN: 1040-0397

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 16 Citations

ISI Web of Science

Scopus - 18 Citations

Scientific classification

CORDIS: Health sciences > Pharmacological sciences

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-003-0EE

DOI: 10.1002/elan.201000301

Resumo (PT): In this work, the construction and performance evaluation of PVC membranes ion-selective electrodes for the determination of tetracycline type antibiotics is described. Electrodes with the best responses were based on plastic membranes containing 31% (w/w) PVC, 68% (w/w) of dibutylphthalate as plasticizer and 1% (w/w) of β-cyclodextrin as ionophore. The electrodes were responsive over 6 months to tetracycline, oxytetracycline, doxycycline and chlortetracycline in glycine buffer solution (pH 2), in the dynamic range 2×10−5–10−2 mol L−1 with a constant slope of about 55 mV/dec To enable large scale analysis reducing wastes as associated costs tubular shape electrodes were coupled to a sequential-injection analysis system and its performance evaluated using pharmaceutical samples and waste waters from a treatment facility. The sample throughput of 51 samples h−1 was enabled by the system as well as results that favorably agree with those provided by chromatographic analysis <br> <br> Keywords:Tetracyclines;Waste water analysis;Potentiometric sensors;Cyclodextrins <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/elan.201000301/abstract "> Texto integral </a> <br> <br>

Abstract (EN): In this work, the construction and performance evaluation of PVC membranes ion-selective electrodes for the determination of tetracycline type antibiotics is described. Electrodes with the best responses were based on plastic membranes containing 31% (w/w) PVC, 68% (w/w) of dibutylphthalate as plasticizer and 1% (w/w) of beta-cyclodextrin as ionophore. The electrodes were responsive over 6 months to tetracycline, oxytetracycline, doxycycline and chlortetracycline in glycine buffer solution (pH 2), in the dynamic range 2 x 10(-5)-10(-2) mol L-1 with a constant slope of about 55 mV/dec To enable large scale analysis reducing wastes as associated costs tubular shape electrodes were coupled to a sequential-injection analysis system and its performance evaluated using pharmaceutical samples and waste waters from a treatment facility. The sample throughput of 51 samples h(-1) was enabled by the system as well as results that favorably agree with those provided by chromatographic analysis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6