Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen

• Type: Article in International Scientific Journal
• Date: 2007

Authors

lopes, cm (Author) Other; lobo, jms (Author) Other; pinto, jf (Author) Other; costa, pc (Author) FFUP

Journal

Title: AAPS PharmSciTech

Vol. 8 No. 3

Pages: E1-E8

ISSN: 1530-9932

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 43 Citations

Scopus - 48 Citations

Other information

Authenticus ID: P-004-C9M

DOI: 10.1208/pt0803051

Abstract (EN): The purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dual-component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug ( ibuprofen). The sustained release effect was achieved with a polymer ( hydroxypropyl methylcellulose [ HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (approximate to 16 or > 24 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release ( zero order) for a long period of time.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8