Substituted Pyrazolo[3,4-d]pyrimidines: Microwave-Assisted, Solvent-Free Synthesis and Biological Evaluation

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Ana M. F. Oliveira-Campos (Author) Other; Aravind Sivasubramanian (Author) Other; Lígia M. Rodrigues (Author) Other; Julio A. Seijas (Author) Other; M. Pilar Vázquez-Tato (Author) Other; Francisco Peixoto (Author) Other; Carlos G. Abreu (Author) Other; Honorina Cidade (Author) FFUP; Ana Elizabete Oliveira (Author) Other; Madalena Pinto (Author) FFUP

Journal

Title: Helvetica Chimica Acta

Pages: 1336-1345

ISSN: 0018-019X

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 20 Citations

ISI Web of Science

Scopus - 22 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-3CY

Resumo (PT): A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines by using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and, in two cases, by X-ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis. <br> <br> Keywords:Pyrazolo[3,4-d]pyrimidines;Microwave-assisted synthesis;Antifungal activity;Botrytis <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/hlca.200890145/abstract"> Texto integral </a> <br> <br>

Abstract (EN): A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines by using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and, in two cases, by X-ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis. <br> <br> Keywords:Pyrazolo[3,4-d]pyrimidines;Microwave-assisted synthesis;Antifungal activity;Botrytis <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/hlca.200890145/abstract"> Full text </a> <br> <br>

Language: English

Type (Professor's evaluation): Scientific