Mitochondria-dependent apoptosis in yeast

• Type: Article in International Scientific Journal
• Date: 2008

Authors

C. Pereira (Author) Other; R.D. Silva (Author) Other; L. Saraiva (Author) FFUP; B. Johansson (Author) Other; M.J. Sousa (Author) Other; M. Côrte-Real (Author) Other

Journal

Title: Biochimica et Biophysica Acta - Molecular Cell Research

Vol. 1783 No. 7

Pages: 1286-1302

ISSN: 0167-4889

Publisher: Elsevier

Indexing

ISI Web of Science

Scopus

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences

Other information

Resumo (PT): Mitochondrial involvement in yeast apoptosis is probably the most unifying feature in the field. Reports proposing a role for mitochondria in yeast apoptosis present evidence ranging from the simple observation of ROS accumulation in the cell to the identification of mitochondrial proteins mediating cell death. Although yeast is unarguably a simple model it reveals an elaborate regulation of the death process involving distinct proteins and most likely different pathways, depending on the insult, growth conditions and cell metabolism. This complexity may be due to the interplay between the death pathways and the major signalling routes in the cell, contributing to a whole integrated response. The elucidation of these pathways in yeast has been a valuable help in understanding the intricate mechanisms of cell death in higher eukaryotes, and of severe human diseases associated with mitochondria-dependent apoptosis. In addition, the absence of obvious orthologues of mammalian apoptotic regulators, namely of the Bcl-2 family, favours the use of yeast to assess the function of such proteins. In conclusion, yeast with its distinctive ability to survive without respiration-competent mitochondria is a powerful model to study the involvement of mitochondria and mitochondria interacting proteins in cell death. <br> <br> Keywords: Yeast apoptosis; Apoptotic regulators; Mitochondrial outer membrane permeabilization; Permeability transition pore; Bcl-2 family; Mitochondrial fragmentation <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T20-4S4JYJT-4&_user=2460038&_coverDate=07%2F31%2F2008&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=738de8cf4e39a0dff8063f5dc566911c&searchtype=a">Texto integral</a> <br> <br>

Abstract (EN): Mitochondrial involvement in yeast apoptosis is probably the most unifying feature in the field. Reports proposing a role for mitochondria in yeast apoptosis present evidence ranging from the simple observation of ROS accumulation in the cell to the identification of mitochondrial proteins mediating cell death. Although yeast is unarguably a simple model it reveals an elaborate regulation of the death process involving distinct proteins and most likely different pathways, depending on the insult, growth conditions and cell metabolism. This complexity may be due to the interplay between the death pathways and the major signalling routes in the cell, contributing to a whole integrated response. The elucidation of these pathways in yeast has been a valuable help in understanding the intricate mechanisms of cell death in higher eukaryotes, and of severe human diseases associated with mitochondria-dependent apoptosis. In addition, the absence of obvious orthologues of mammalian apoptotic regulators, namely of the Bcl-2 family, favours the use of yeast to assess the function of such proteins. In conclusion, yeast with its distinctive ability to survive without respiration-competent mitochondria is a powerful model to study the involvement of mitochondria and mitochondria interacting proteins in cell death. <br> <br> Keywords: Yeast apoptosis; Apoptotic regulators; Mitochondrial outer membrane permeabilization; Permeability transition pore; Bcl-2 family; Mitochondrial fragmentation <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T20-4S4JYJT-4&_user=2460038&_coverDate=07%2F31%2F2008&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=738de8cf4e39a0dff8063f5dc566911c&searchtype=a"> Full text</a> <br> <br>

Language: English

Type (Professor's evaluation): Scientific