Compressed mini-tablets as a biphasic delivery system

• Type: Article in International Scientific Journal
• Date: 2006

Authors

lopes, cm (Author) Other; lobo, jms (Author) Other; pinto, jf (Author) Other; costa, p (Author) FFUP

Journal

Title: International Journal of Pharmaceutics

Vol. 323 No. 1

Pages: 93-100

ISSN: 0378-5173

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 58 Citations

Scopus - 86 Citations

Other information

Authenticus ID: P-004-GM3

DOI: 10.1016/j.ijpharm.2006.05.063

Abstract (EN): Compressed mini-tablets systems are presented as a biphasic delivery system designed for zero-order sustained drug release. The outer layer that fills the void spaces between the mini-tablets was formulated to release the drug in a very short time (fast release), while the mini-tablets provided a prolonged release. Different composition (HPMC or EC) and number (10 or 2 1) of mini-tablets were used to obtain different drug release rates. The in vitro performance of these systems showed the desired biphasic behaviour: the drug contained in the fast releasing phase (powder enrobing the mini-tablets) dissolved within the first 2 min, whereas the drug contained in the mini-tablets was released at different rates, depending up on formulation. Based on the release kinetic parameters calculated, it can be concluded that mini-tablets containing HPMC were particularly suitable approaching to zero-order (constant) release over 8 h time periods.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8