Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Marieta L C Passos (Author) Other; Lucia L M F S Saraiva (Author) FFUP; Jose L F C Lima (Author) FFUP; Gracas G A Korn (Author) Other

Journal

Title: Journal of the Brazilian Chemical Society

Vol. 19

Pages: 563-568

ISSN: 0103-5053

Publisher: Sociedade Brasileira de Quimica

Indexing

ISI Web of Knowledge - 12 Citations

ISI Web of Science

Scopus - 13 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-3Z8

DOI: 10.1590/s0103-50532008000300027

Resumo (PT): A mechanized system for the determination of β–blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL. <br> <br> Keywords: beta-blockers, sequential injection analysis, SIA, spectrophotometry, pharmaceutical formulations <br> <a target="_blank" href="http://jbcs.sbq.org.br/jbcs/2008/vol19_n3/26-07396AR.pdf"> Texto integral </a> <br> <br>

Abstract (EN): A mechanized system for the determination of beta-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these Substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1 acebutolol (32.85 - 140 mg U) and propranolol (16.58 - 120 mg U). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6