Delivery of Drugs from Laminar Co-Extrudates Manufactured by a Solvent-Free Process at Room Temperature

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Oliveira, G (Author) Other; Wahl, MA (Author) Other; Pinto, JF (Author) Other

Journal

Title: Journal of Pharmaceutical Sciences

Vol. 103

Pages: 3501-3510

ISSN: 0022-3549

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 2 Citations

Other information

Authenticus ID: P-009-YG0

DOI: 10.1002/jps.24133

Abstract (EN): This work aims to design and manufacture laminar co-extrudates as a new dosage form for the delivery of drugs. Co-extrudates made of lipid-based materials with a laminar shape were manufactured at room temperature in the absence of solvents and assessed over time for their mechanical properties (bending strength, deformation, stiffness, and elasticity), density, porosity, thermal behavior and main mechanism of drug release. The study has shown that the extrusion force at steady state increased with the extrusion rate and with the number of layers. The bending strength and stiffness of extrudates increased over time. Laminar co-extrudates with higher number of layers presented a decreasing dissolution efficiency of 38.3 +/- 0.6%, 23.0 +/- 0.2%, and 12.3 +/- 0.2%, for mono-, bi-, and trilayer, respectively. After 90 days, the density, the deformation, and elasticity decreased: trilayer extrudates were the denser and the ones to present the lowest ability to deform and the highest elasticity, whereas monolayer extrudates were the less dense presenting the highest ability to deform. Changes were more evident in the first days after manufacture leading to stabilization over time. Laminar (co-)extrudates have been confirmed as an innovative dosage form for tailored delivery of drugs made without solvents at room temperature. (c) 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3501-3510, 2014

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10