Antifungal activity of the essential oil of Thymus capitellatus against Candida, Aspergillus and dermatophyte strains

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Ligia Ribeiro Salgueiro (Author) Other; Eugenia Pinto (Author) FFUP; Maria Jose Goncalves (Author) Other; Ines Costa (Author) Other; Ana Palmeira (Author) Other; Carlos Cavaleiro (Author) Other; Cidalia Pina Vaz (Author) FMUP; Acacio Goncalves Rodrigues (Author) FMUP; Jose Martinez de Oliveira (Author) Other

Journal

Title: Flavour and Fragrance Journal

Vol. 21 No. 5

Pages: 749-753

ISSN: 0882-5734

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 27 Citations

ISI Web of Science

Scopus - 29 Citations

Scientific classification

FOS: Agrarian Sciences > Other Agrarian Sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-HGM

DOI: 10.1002/ffj.1610

Resumo (PT): The antifungal activity of Thymus capitellatus oils on Candida, Aspergillus and dermatophyte strains were studied. The essential oils were obtained from the aerial parts of the plants by water distillation and analysed by GC and GC–MS. Three chemotypes were characterized: 1,8-cineole (47.5%), 1,8-cineole/borneol (28.8% and 19.5%, respectively) and 1,8-cineole/linalyl acetate/linalool (27.5%, 20.0% and 17.0%, respectively). The minimal inhibitory concentration (MIC) determined according to the NCCLS protocols (M27-A and M38-P) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida (seven clinical isolates and three ATCC type strains), Aspergillus (five clinical isolates, two CECT and two ATCC type strains) and five dermatophyte clinical fungi strains. The oils exhibited antifungal activity for the dermatophyte strains, with MIC values of 0.32–1.25 µl/ml; the chemotype 1,8-cineole/linalyl acetate/linalool proved to be more active. The highest antifungal activity of this oil can be associated with the contribution of the linalyl acetate. In the other hand, all samples showed low activity against Candida and Aspergillus strains <br> Keywords:Thymus capitellatus;Lamiaceae;essential oil composition;antifungal activity <br> <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/ffj.1610/abstract"> Texto integral</a> <br> <br>

Abstract (EN): The antifungal activity of Thymus capitellatus oils on Candida, Aspergillus and dermatophyte strains were studied. The essential oils were obtained from the aerial parts of the plants by water distillation and analysed by GC and GC-MS. Three chemotypes were characterized: 1,8-cineole (47.5%), 1,8-cineole/borneol (28.8% and 19.5%, respectively) and 1,8-cineole/linalyl acetate/linalool (27.5%, 20.0% and 17.0%, respectively). The minimal inhibitory concentration (MIC) determined according to the NCCLS protocols (M27-A and M38-P) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida (seven clinical isolates and three ATCC type strains), Aspergillus (five clinical isolates, two CECT and two ATCC type strains) and five dermatophyte clinical fungi strains. The oils exhibited antifungal activity for the dermatophyte strains, with MIC values of 0.32-1.25 mu l/ml; the chemotype 1,8-cineole/linalyl acetate/linalool proved to be more active. The highest antifungal activity of this oil can be associated with the contribution of the linalyl acetate. In the other hand, all samples showed low activity against Candida and Aspergillus strains. Copyright (c) 2006 John Wiley & Sons, Ltd.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5