Fractal protein structure revisited: Topological, kinetic and thermodynamic relationships

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Tejera, E (Author) Other; Machado, A (Author) Other; Rebelo, I (Author) FFUP; Nieto Villar, J (Author) Other

Journal

Title: Physica A: Statistical Mechanics and its Applications

Vol. 388

Pages: 4600-4608

ISSN: 0378-4371

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 14 Citations

ISI Web of Science

Scopus - 15 Citations

Scientific classification

CORDIS: Health sciences

FOS: Natural sciences > Physical sciences

Other information

Authenticus ID: P-003-EVW

DOI: 10.1016/j.physa.2009.07.015

Resumo (PT): The present work explored the definitions and calculations of fractal dimensions in protein structures and the corresponding relationships with the protein class, secondary structure contents, fold type as well as kinetic and thermodynamic parameters like the folding and unfolding rate, the folding–unfolding free energy and others. The results showed a positive correlation of some fractal exponents with the kinetic and thermodynamic variables even considering the effect of the protein length. On the other hand the influences of secondary structures types, especially the turn conformation are significant as well as the fractal exponent profiles according to class and fold types. <br> <br> Keywords: Fractal dimension; Protein length; Thermodynamic; Folding rate; Spectral dimension; Contact map <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TVG-4WSRF2K-7&_user=2460038&_coverDate=11%2F01%2F2009&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=e903b2cef67cc3e1800f3eba14197bae "> Texto integral </a> <br> <br>

Abstract (EN): The present work explored the definitions and calculations of fractal dimensions in protein structures and the corresponding relationships with the protein class, secondary structure contents, fold type as well as kinetic and thermodynamic parameters like the folding and unfolding rate, the folding-unfolding free energy and others. The results showed a positive correlation of some fractal exponents with the kinetic and thermodynamic variables even considering the effect of the protein length. On the other hand the influences of secondary structures types, especially the turn conformation are significant as well as the fractal exponent profiles according to class and fold types.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9