ANANDAMIDE-INDUCED CELL DEATH IN RAT PRIMARY DECIDUAL CELL CULTURES

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Bruno Fonseca (Author) Other; Georgina Correia-da-Silva (Author) FFUP; Stephen Bell (Author) Other; Natércia Teixeira (Author) FFUP

Journal

Title: Placenta

Vol. 29 No. 8

Pages: A39-A39

ISSN: 0143-4004

Publisher: Elsevier

Indexing

ISI Web of Science

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences

Other information

Resumo (PT): Since anandamide has revealed proapoptotic activity (2), it may be speculated that AEA may be involved in the control of proliferation and regression of decidual tissues, or at least, it may have a role in this complex process as anandamide-binding receptors are still present in decidualized cells until regression. Combining our previous results demonstrating the expression of cannabinoid receptors in decidual cells, it is possible to consider an action mediated by AEA through these receptors in this complex mechanism of decidualization. We are presently undertaking experiments to clarify whether cannabinoid receptors activation is detrimental or crucial to normal apoptosis during decidual regression. <br> <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPD-4T29WJH-2&_user=2460038&_coverDate=08%2F31%2F2008&_rdoc=16&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236988%232008%23999709991%23696019%23FLA%23display%23Volume)&_cdi=6988&_sort=d&_docanchor=&_ct=18&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=38b5820cc7d3fd7ffbc2142780c2232a"> Texto integral</a> <br> <br>

Abstract (EN): Since anandamide has revealed proapoptotic activity (2), it may be speculated that AEA may be involved in the control of proliferation and regression of decidual tissues, or at least, it may have a role in this complex process as anandamide-binding receptors are still present in decidualized cells until regression. Combining our previous results demonstrating the expression of cannabinoid receptors in decidual cells, it is possible to consider an action mediated by AEA through these receptors in this complex mechanism of decidualization. We are presently undertaking experiments to clarify whether cannabinoid receptors activation is detrimental or crucial to normal apoptosis during decidual regression. <br> <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPD-4T29WJH-2&_user=2460038&_coverDate=08%2F31%2F2008&_rdoc=16&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236988%232008%23999709991%23696019%23FLA%23display%23Volume)&_cdi=6988&_sort=d&_docanchor=&_ct=18&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=38b5820cc7d3fd7ffbc2142780c2232a"> Full text </a> <br> <br>

Language: Portuguese

Type (Professor's evaluation): Scientific