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First Report on Cydonia oblonga Miller Anticancer Potential: Differential Anti proliferative Effect against Human Kidney and Colon Cancer Cells

Title
First Report on Cydonia oblonga Miller Anticancer Potential: Differential Anti proliferative Effect against Human Kidney and Colon Cancer Cells
Type
Article in International Scientific Journal
Year
2010
Authors
Marcia Carvalho
(Author)
Other
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Branca M Silva
(Author)
Other
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Renata Silva
(Author)
Other
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Maria L Bastos
(Author)
FFUP
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Journal
Vol. 58
Pages: 3366-3370
ISSN: 0021-8561
Indexing
Publicação em ISI Web of Science ISI Web of Science
Pubmed / Medline
Scientific classification
FOS: Agrarian Sciences > Other Agrarian Sciences
CORDIS: Health sciences > Pharmacological sciences > Pharmacognosy
Other information
Authenticus ID: P-003-87E
Resumo (PT): The present study reports the phenolic profile and antiproliferative properties of quince (Cydonia oblonga Miller) leaf and fruit (pulp, peel, and seed) against human kidney and colon cancer cells. The phenolic profiles of quince methanolic extracts were determined by high-performance liquid chromatography (HPLC)/diode array detector (DAD). 5-O-Caffeoylquinic acid was always one of the two major phenolic compounds present in all extracts, except for seed. Our results revealed that quince leaf and fruit extracts exhibited distinctive antiproliferative activities. The extracts from quince leaf showed concentration-dependent growth inhibitory activity toward human colon cancer cells (IC50 = 239.7 ± 43.2 μg/mL), while no effect was observed in renal adenocarcinoma cells. Concerning the fruit, seed extracts exhibited no effect on colon cancer cell growth, whereas strong antiproliferative efficiency against renal cancer cells was observed for the highest concentration assayed (500 μg/mL). The antiproliferative activity of pulp and peel extracts was low or absent in the selected range of extract concentrations. This is the first report showing that C. oblonga may be useful as a cancer chemopreventive and/or chemotherapeutic agent. <br> <br> Keywords (keywords): Cydonia oblonga Miller; quince; phenolic compounds; antiproliferative activity; kidney cancer; colon cancer <br> <a target="_blank" href="http://pubs.acs.org/doi/abs/10.1021/jf903836k "> Texto integral</a> <br> <br>
Abstract (EN): The present study reports the phenolic profile and antiproliferative properties of quince (Cydonia oblonga Miller) leaf and fruit (pulp, peel, and seed) against human kidney and colon cancer cells. The phenolic profiles of quince methanolic extracts were determined by high-performance liquid chromatography (HPLC)/diode array detector (DAD). 5-O-Caffeoylquinic acid was always one of the two major phenolic compounds present in all extracts, except for seed. Our results revealed that quince leaf and fruit extracts exhibited distinctive antiproliferative activities. The extracts from quince leaf showed concentration-dependent growth inhibitory activity toward human colon cancer cells (IC(50) = 239.7 +/- 43.2 mu g/mL), while no effect was observed in renal adenocarcinoma cells. Concerning the fruit, seed extracts exhibited no effect on colon cancer cell growth, whereas strong antiproliferative efficiency against renal cancer cells was observed for the highest concentration assayed (500 mu g/mL). The anti proliferative activity of pulp and peel extracts was low or absent in the selected range of extract concentrations. This is the first report showing that C. oblonga may be useful as a cancer chemopreventive and/or chemotherapeutic agent.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 5
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