Characterization of Polymeric Solutions as Injectable Vehicles for Hydroxyapatite Microspheres

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Serafim M Oliveira (Author) Other; Isabel F Almeida (Author) FFUP; Paulo C Costa (Author) FFUP; Cristina C Barrias (Author) Other; Rosa R P Pena Ferreira (Author) Other; Fernanda F Bahia (Author) Other; Mario A Barbosa (Author) FEUP

Journal

Title: AAPS PharmSciTech

Vol. 11 No. 2

Pages: 852-858

ISSN: 1530-9932

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 22 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-5SE

DOI: 10.1208/s12249-010-9447-3

Abstract (EN): A polymeric solution and a reinforcement phase can work as an injectable material to fill up bone defects. However, the properties of the solution should be suitable to enable the transport of that extra phase. Additionally, the use of biocompatible materials is a requirement for tissue regeneration. Thus, we intended to optimize a biocompatible polymeric solution able to carry hydroxyapatite microspheres into bone defects using an orthopedic injectable device. To achieve that goal, polymers usually regarded as biocompatible were selected, namely sodium carboxymethylcellulose, hydroxypropylmethylcellulose, and Na-alginate (ALG). The rheological properties of the polymeric solutions at different concentrations were assessed by viscosimetry before and after moist heat sterilization. In order to correlate rheological properties with injectability, solutions were tested using an orthopedic device applied for minimal invasive surgeries. Among the three polymers, ALG solutions presented the most suitable properties for our goal and a non-sterile ALG 6% solution was successfully used to perform preliminary injection tests of hydroxyapatite microspheres. Sterile ALG 7.25% solution was found to closely match non-sterile ALG 6% properties and it was selected as the optimal vehicle. Finally, sterile ALG 7.25% physical stability was studied at different temperatures over a 3-month period. It was observed that its rheological properties presented minor changes when stored at 25A degrees C or at 4A degrees C.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7