Scaffolds for drug delivery and tissue engineering: The role of genetics

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Zielinska, A (Author) Other; Karczewski, J (Author) Other; Eder, P (Author) Other; Kolanowski, T (Author) Other; Szalata, M (Author) Other; Wielgus, K (Author) Other; Szalata, M (Author) Other; Kim, D (Author) Other; Shin, SR (Author) Other; Slomski, R (Author) Other; Souto, EB (Author) FFUP

Journal

Title: Journal of Controlled Release

Vol. 359

Pages: 207-223

ISSN: 0168-3659

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 2 Citations

Scopus

Other information

Authenticus ID: P-00Y-Z2E

DOI: 10.1016/j.jconrel.2023.05.042

Abstract (EN): Scaffolds are implants commonly used to deliver cells, drugs, and genes into the body. Their regular porous structure ensures the proper support for cell attachment, proliferation, differentiated function, and migration. Techniques to fabricate a scaffold include leaching, freeze-drying, supercritical fluid technology, thermally induced phase separation, rapid prototyping, powder compaction, sol-gel, and melt molding. Gene delivery from the scaffold represents a versatile approach to influence the environment for managing cell function. Scaffolds can be used for various tissue engineering purposes, e.g. bone formation, periodontal regeneration, cartilage development, artificial corneas, heart valves, tendon repair, or ligament replacement. Moreover, they are also instrumental in cancer therapy, inflammation, diabetes, heart disease, and wound dressings. Scaffolds provide a platform to extend the delivery of drugs and genetic materials at a controlled timeframe, besides potentially being used to prevent infection upon surgery and other chronic diseases, provided that they can be formulated with specific medicines. This review discusses the need to design advanced functional scaffolds with the potential for modified drug delivery and tissue engineering in a synergistic approach. Special attention is given to works published in 2023 to generate the bibliometric map.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17