Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part II - applications and preclinical advancements

• Type: Another Publication in an International Scientific Journal
• Date: 2024

Authors

Fathi, F (Author) Other; Machado, TOX (Author) Other; Kodel, H (Author) Other; Portugal, I (Author) Other; Ferreira, IO (Author) Other; Zielinska, A (Author) Other; Beatriz B P P Oliveira (Author) FFUP; Souto, EB (Author) Other

Journal

Title: Expert Opinion on Drug Delivery

Pages: 1-9

ISSN: 1742-5247

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-017-4N6

DOI: 10.1080/17425247.2024.2410949

Abstract (EN): IntroductionNumerous purified bioactive compounds, crude extracts, and essential oils have demonstrated potent antioxidant, antimicrobial, anti-inflammatory, and antiviral properties, particularly in vitro or in silico; however, their in vivo applications are hindered by inadequate absorption and distribution in the organism. The incorporation of these phytochemicals into solid lipid nanoparticles (SLN) or nanostructured lipid carriers (NLC) has demonstrated significant advancements and represents a viable approach to improve their bioavailability through different administration routes.Areas coveredThis review discusses the potential applications of SLN and NLC, loading bioactive compounds sourced from plants for the treatment of several diseases. An overview of the preclinical developments on the use of these lipid nanoparticles is also provided as well as the requisites to be launched on the market.Expert opinionMedicinal plants have gained even more value for the pharmaceutical industries and their customers, leading to many studies exploring their therapeutic potential. Several bioactives derived from plants with antiviral, anticancer, neuroprotective, antioxidant, and antiaging properties have been proposed and loaded into lipid nanoparticles. In vitro and invivo studies corroborate the added value of SLN/NLC to improve the bioavailability of several bioactives. Surface modification to increase their stability and target delivery should be considering.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9