Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Januario, AP (Author) Other; Felix, R (Author) Other; Felix, C (Author) Other; Reboleira, J (Author) Other; Patricia Valentao (Author) FFUP; Lemos, MFL (Author) Other

Journal

Title: Pharmaceutics

Vol. 13

Final page: 1930

ISSN: 1999-4923

Publisher: MDPI

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00V-QEQ

DOI: 10.3390/pharmaceutics13111930

Abstract (EN): Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 32