Photomodulation Approaches to Overcome Antimicrobial Resistance

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Sarabando, SN (Author) Other; Palmeira, A (Author) FFUP; Emilia Sousa (Author) FFUP; Faustino, MAF (Author) Other; Monteiro, CJP (Author) Other

Journal

Title: Pharmaceuticals

Vol. 212

Final page: 682

ISSN: 1424-8247

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Y-G5M

DOI: 10.3390/ph16050682

Abstract (EN): Photopharmacology is an approach that aims to be an alternative to classical chemotherapy. Herein, the different classes of photoswitches and photocleavage compounds and their biological applications are described. Proteolysis targeting chimeras (PROTACs) containing azobenzene moieties (PHOTACs) and photocleavable protecting groups (photocaged PROTACs) are also mentioned. Furthermore, porphyrins are referenced as successful photoactive compounds in a clinical context, such as in the photodynamic therapy of tumours as well as preventing antimicrobial resistance, namely in bacteria. Porphyrins combining photoswitches and photocleavage systems are highlighted, taking advantage of both photopharmacology and photodynamic action. Finally, porphyrins with antibacterial activity are described, taking advantage of the synergistic effect of photodynamic treatment and antibiotic therapy to overcome bacterial resistance.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 36