In vitro mineralisation of human bone marrow cells cultured on Bonelike®

• Type: Article in International Scientific Journal
• Date: 2004

Authors

M. A. Costa (Author) Other; M. Gutierres (Author) Other; L. Almeida (Author) Other; Maria Ascensão Lopes (Author) FEUP; José Domingos Santos (Author) FEUP; M. H. Fernandes (Author) Other

Journal

Title: Key Engineering Materials

Vol. 254-256

Pages: 821-823

ISSN: 1013-9826

Publisher: Trans Tech Publications Ltd

Indexing

ISI Web of Science

Scientific classification

FOS: Engineering and technology > Medical engineering

Other information

DOI: 10.4028/www.scientific.net/KEM.254-256.821

Abstract (EN): Bonelike(R) is a CaO-P2O5 based glass-reinforced hydroxyapatite (HA) designed to mimic the inorganic composition of the bone tissue. This work evaluates the response of human bone marrow cells to Bonelike(R) concerning cell proliferation and osteoblast differentiation. HA was used as control material. Results showed that Bonelike(R) allowed the proliferation of bone marrow cells and their complete differentiation, as evidenced by the formation of cell-mediated mineralisation. In comparison with HA, Bonelike(R) had a positive effect on the expression of alkaline phosphatase and also on the formation of a mineralised matrix, two osteoblast markers.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3